Results 241 to 250 of about 116,566 (305)

MiR‐145‐5p Attenuates Doxorubicin‐Induced Heart Injury Through Targeting Cardiomyocyte Pyroptosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Doxorubicin (DOX), a potent anthracycline chemotherapeutic, exhibits dose‐dependent cardiotoxicity that limits its clinical utility. Although miR‐145‐5p demonstrates cardioprotective properties in cardiovascular diseases, its role in DOX‐induced cardiomyopathy remains undefined.
Xing‐Tao Chen, Yong‐Hong Yu, Yan‐Hua Du, Lin Xu, Xiang‐Ping Meng   +4 more
wiley   +1 more source

Autophagy targeted nano-medicine in norphytane atrophic arthritis model: Beclin1/XBP/PTEN/STAT-3A genetic profile. [PDF]

Future Sci OA
O Kadry M, Abdel-Megeed RM.
europepmc   +1 more source

Role of COL1A1 and CD44 in Modulating JAK1/STAT3‐Mediated Autophagy for Spinal Cord Injury Recovery

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Spinal cord injury (SCI) is a severe trauma to the central nervous system that often leads to motor and sensory dysfunction in patients, severely affecting their quality of life. Autophagy plays a role in the pathological process of SCI, but the specific mechanism of autophagy in this case is unknown.
Chun‐Lei Li, Qian Zhang, Li Fang, Ling‐Yun Zhou   +3 more
wiley   +1 more source

Platelet Autophagy as a Druggable Intracellular Pathway: Therapeutic Opportunities in Thromboinflammatory Diseases. [PDF]

Pharmaceutics
Yen TL, Jan JS, Teng RD, Ko PC, Taliyan R, Yang CH, Sun JM, Sheu JR.   +7 more
europepmc   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Cyclic tensile loading regulates nucleus pulposus cell autophagy through mitochondrial dynamics: molecular mechanisms and implications. [PDF]

J Transl Med
Xue S, Soleimani Samarkhazan H.
europepmc   +1 more source

Proteomics of Nitrotyrosine: Integrating Mass Spectrometry and Immunodetection in Redox‐Driven Pathology

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley   +1 more source

Molecular subtyping and immune microenvironment heterogeneity in pediatric influenza-associated prolonged multiple organ dysfunction syndrome. [PDF]

Transl Pediatr
Chi M, Wang L, Bi W, Liu F, Liu S, Zhang D.   +5 more
europepmc   +1 more source

Restoration of Immune Surveillance in Prostate Cancer Prevention by Sulforaphane in Hi‐Myc Mice

Molecular Carcinogenesis, EarlyView.
ABSTRACT Oral administration of broccoli constituent sulforaphane (SFN) prevents prostate cancer development in preclinical mouse models. However, the mechanism(s) underlying prostate cancer prevention by SFN are not fully understood. In this study, we used a human relevant mouse model (Hi‐Myc mice) to demonstrate restoration of immune surveillance by ...
Krishna B. Singh, Eun‐Ryeong Hahm, Joshi J. Alumkal, Shivendra V. Singh   +3 more
wiley   +1 more source

Autophagy in Rheumatoid Arthritis: Molecular Mechanisms, Diagnostic Biomarkers, and Emerging Therapeutic Strategies. [PDF]

Inflammation
Nasrollahizadeh A, Rahmati S, Chahkand MSG, Moallem FE, Azarm E, Dadkhah PA, Karimi M, Amini-Salehi E, Karimi MA.   +8 more
europepmc   +1 more source