Results 231 to 240 of about 75,578 (255)

Autophagy biomarkers in patients with acute myocardial infarction

European Heart Journal, 2022
Abstract Introduction Acute myocardial infarction (AMI) is still one of leading cause for mortality and disability in cardiovascular disease [1]. Autophagy is an intracellular mechanism involved in the elimination and the recycling of proteins and organelles by lysosomes [2].
M G Kong, J Suh, Y H Cho, N H Lee, H W Park   +4 more
openaire   +1 more source

A Study on Autophagy Related Biomarkers in Alzheimer’s Disease Based on Bioinformatics

Cellular and Molecular Neurobiology, 2023
Alzheimer's disease (AD) is a neurodegenerative disease with an annual incidence increase that poses significant health risks to people. However, the pathogenesis of AD is still unclear. Autophagy, as an intracellular mechanism can degrade damaged cellular components and abnormal proteins, which is closely related to AD pathology. The goal of this work
Jian, Li, Wenjia, Liu, Wen, Sun, Xin, Rao, Xiaodong, Chen, Liyang, Yu   +5 more
openaire   +2 more sources

Effects of stimulation of autophagy on the urinary excretion of biomarkers of the oxidative status

Aging Clinical and Experimental Research, 2013
Autophagy, a health-promoting lysosomal degradation pathway that controls the quality of the cytoplasm by eliminating protein aggregates and damaged organelles including 8-OHdG-rich mitochondria, is under investigation as a target for prevention and/or treatment of several human diseases and decelerating aging.
Gabriella, Cavallini, Alessio, Donati, Biagio, Capasso, Michele, Fella, Vincenzo, Leone, Gaetano, Pezzella, Giorgio Cosimo, Romano, Angelo, Vagali, Ettore, Bergamini   +8 more
openaire   +2 more sources

May Autophagy be a Novel Biomarker and Antitumor Target in Colorectal Cancer?

Biomarkers in Medicine, 2016
Autophagy is a catabolic process associated with intracellular self-digestion of damaged organelles or redundant proteins enabling maintenance of cell homeostasis. It is accepted that impaired autophagy is closely linked to cancer development and has been extensively studied in a variety of malignancies including colorectal cancer (CRC) to elucidate ...
Justyna, Gil, Karolina A, Pesz, Maria M, Sąsiadek   +2 more
openaire   +3 more sources

Increased formation of neutrophil extracellular traps induced by autophagy and identification of autophagy‐related biomarkers in systemic lupus erythematosus

Experimental Dermatology, 2023
Abstract Abnormal death of neutrophils and the subsequent ineffective clearance of cell fragments result in production of autoantigens that can lead to systemic lupus erythematosus (SLE). Excessive formation of neutrophil extracellular traps (NETs) can trigger the synthesis of pro‐inflammatory cytokines such as type I interferons ...
Mingfang Li, Luobei Weng, Datang Yu, Guofei Yang, Jin Hao   +4 more
openaire   +2 more sources

Identification of autophagy-related biomarkers in prostate cancer prognosis

Human Cell
Prostate cancer is the second leading cause of cancer-related deaths in males that has an unfavorable outcome. Autophagy-related genes (ARGs) contribute to the process of tumorigenesis and metastasis of prostate cancer. This study aimed to identify ARGs that could serve as reliable and non-invasive biomarkers for evaluating prostate cancer prognosis ...
Yancheng Di, Linlin Zhao, Lingling Zhang, Lei Chen   +3 more
openaire   +2 more sources

Identification of biomarkers associated with pyroptosis and autophagy in facet joint osteoarthritis

Clinical and Experimental Rheumatology
Facet joint osteoarthritis (FJOA) is a degenerative spinal joint condition causing low back pain due to cartilage loss and joint damage. Although some studies have highlighted the importance of pyroptosis or autophagy in cartilage loss under FJOA, no report has identified the biomarkers between the two biological events.
Xun, Zhou, Chaochen, Li, Tianyi, Wang, Qianqiu, Li, Guanhua, Xu, Zhiming, Cui   +5 more
openaire   +2 more sources

Identification of autophagy-related biomarkers in the circulatory system of ischemic stroke

Neurological Research
Increasing evidence indicates autophagy's dual role in ischemic stroke (IS), though its mechanisms and biomarkers remain unclear. This study analyzes autophagy-related genes (ARGs) and constructs a circRNA-miRNA-mRNA network to identify key ARGs and their interactions.Differentially expressed genes from GEO were intersected with HADb-derived autophagy ...
Yuyu Xu, Jinshan Duan, Deling Zhong, Ming Yuan, Guohai Zhang, Zheli Zhu, Yani Xie   +6 more
openaire   +2 more sources

Autophagy as a Biomarker of Cytotoxicity

2022
openaire   +1 more source

Autophagy-related proteins: Potential diagnostic and prognostic biomarkers of aging-related diseases

Ageing Research Reviews, 2023
Caterina Miceli, Manuela Léri, Massimo Stefani   +2 more
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