Results 211 to 220 of about 116,566 (305)

Inflammation, cell death, and lncRNAs: unraveling the mechanisms of sepsis-associated acute kidney injury. [PDF]

Front Immunol
Ren D, Liu Q, Liao H, Wang M, Wang Y, Guo W, Duan C, Zhou Y, Luo Z.   +8 more
europepmc   +1 more source

Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis

ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.
Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen, Jiahao Shi, Yue Wu, Lizhu Miao, Zilin Wang, Yixuan Wang, Siwei Xu, Yu Lou   +7 more
wiley   +1 more source

Single-cell and multi-omics analysis identifies mitophagy-related biomarkers and therapeutic targets in ischemic stroke. [PDF]

Sci Rep
Cao Z, Wang Y, Sun M, Du R, Feng X, Wang L, Zhao Z, Sun W.   +7 more
europepmc   +1 more source

Relationship between hTERT levels and oxidative stress in epilepsy patients

Epilepsia Open, EarlyView.
Abstract Objective Human telomerase reverse transcriptase (hTERT) is a key determinant of telomere maintenance and cellular aging. Oxidative stress plays a role in neurodegenerative processes by causing cellular damage through increased reactive oxygen species.
Muhammed Mehdi Üremiş, Deniz Tuncel Berktaş, Nuray Üremiş, Fatma İnanç Tolun   +3 more
wiley   +1 more source

Empagliflozin attenuates dexamethasone-induced non-alcoholic steatohepatitis by regulation of ferroptosis, inflammation and autophagy. [PDF]

Front Pharmacol
Alharbi NS, Abdelmageed ME, Nader MA, Serrya MS.   +3 more
europepmc   +1 more source

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

Exosomal non-coding RNAs in autoimmune diseases: molecular mechanisms and potential applications. [PDF]

Front Immunol
Wu Y, Li X, Jin Y, Mao F, Zhang L.
europepmc   +1 more source

CSF microtubule-associated protein 1 light chain 3A and 3B levels are associated with tau pathology and Alzheimer's disease risk through amyloid deposition and microglial signaling. [PDF]

J Neuroinflammation
Guo HH, Su D, Song B, Geng Z, Wang L, Wang W, Hu W, Li X, Li W, Zhang G, Fang M, Dai Y, Hu P, Wu X, Wang K, Wei L, Alzheimer’s Disease Neuroimaging Initiative.   +16 more
europepmc   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Clinical implications of PD‐L1 expression in oncogene‐driven NSCLC: Differential responses to targeted agents and immune checkpoint inhibitors

International Journal of Cancer, EarlyView.
What's New? PD‐L1 is a reliable biomarker for predicting immunotherapy efficacy in patients with non‐small‐cell lung cancer lacking oncogenic driver mutations. However, its significance in patients with driver mutations remains unclear. In this study of 273 patients with stage IV non–‐small‐cell lung cancer harboring diverse driver alterations and PD ...
Xiaoxiao Fan, Chenxi Wei, Minjun Rong, Shengnan Wang, Jiaying Wang, Xiaohan Wang, Xiao Han, Xue Meng   +7 more
wiley   +1 more source