Results 1 to 10 of about 218,590 (260)

Performance of four computer-coded verbal autopsy methods for cause of death assignment compared with physician coding on 24,000 deaths in low- and middle-income countries [PDF]

, 2014
BACKGROUND: Physician-coded verbal autopsy (PCVA) is the most widely used method to determine causes of death (CODs) in countries where medical certification of death is uncommon.
Leitao, Jordana, Tollman, Stephen, Tollman, Stephen,, Pierre Miasnikof, Rajesh Kumar, Aleksandrowicz, Lukasz, Lu, Ying, Kumar, Rajesh, Dewan Alam, Prabhat Jha, Nikita Desai, Jordana Leitao, Abhishek Singh, Jha, Prabhat, Nikita Desai, Desai, Nikita, Miasnikof, Pierre, Faujdar Ram, Ram, Faujdar, Byass, Peter, Lukasz Aleksandrowicz, Mee, Paul,, Alam, Dewan, Peter Byass, Singh, Abhishek, Rathi, Suresh K, Stephen Tollman, Ying Lu, Mee, Paul, Jordana Leitao, Paul Mee, Byass, Peter,, Suresh Kumar Rathi, Rathi, Suresh Kumar   +33 more
core   +1 more source

Revising the WHO verbal autopsy instrument to facilitate routine cause-of-death monitoring. [PDF]

, 2013
OBJECTIVE: Verbal autopsy (VA) is a systematic approach for determining causes of death (CoD) in populations without routine medical certification. It has mainly been used in research contexts and involved relatively lengthy interviews.
Kathleen Kahn, Honorati Masanja, Leitao, Jordana, Annunziata, Giuseppe, Fatima Marinho, Kebede, Derege, Kumar, Vishwajeet, Bahl, Rajiv, Daniel Chandramohan, Rajiv Bahl, Alley, William Soumbey, Sennen Hounton, Spiegel, Paul, Abraham Hodgson, Elizabeth França, Mathai, Matthews, Erin Nichols, Amexo, Marc, Hodgson, Abraham, Kanitta Bundhamcharoen, Jun Gao, Loyola, Enrique, Notzon, Francis, Bundhamcharoen, Kanitta, Ties Boerma, Peter Byass, Chandramohan, Daniel, Francis Notzon, Jordana Leitao, Giuseppe Annunziata, Byass, Peter,, Osman Sankoh, Sankoh, Osman, Anand Krishnan, Kidist Bartolomeus, Chanpen Choprapawon, Mohamed Ali, Choprapawon, Chanpen, Marinho, Fatima, Muhe, Lulu, Rasooly, Mohammad Hafiz, Froen, Frederik, AbouZahr, Carla, Vishwajeet Kumar, Fottrell, Edward, Ustun, Bedirhan, Frederik Frøen, Gao, Jun, Ali, Mohamed, Chikersal, Jyotsna, Doris Chou, Lulu Muhe, Jakob, Robert, Jyotsna Chikersal, Frøen, Frederik, Krishnan, Anand, Boerma, Ties, de Savigny, Don, Edward Fottrell, Carla Abouzahr, Marc Amexo, Paul Spiegel, Robert Jakob, Gihan Gewaifel, França, Elizabeth, Bedirhan Ustun, Byass, Peter, Bartolomeus, Kidist, Kahn, Kathleen, William Soumbey Alley, Chou, Doris, Masanja, Honorati, Derege Kebede, Hounton, Sennen, Don de Savigny, Matthews Mathai, Gewaifel, Gihan, Mohammad Hafiz Rasooly, Nichols, Erin, Enrique Loyola   +79 more
core   +1 more source

The maternal autopsy [PDF]

Journal of Clinical Pathology, 1982
Careful study of reports prepared for the Confidential Enquiries into Maternal Deaths in England and Wales has made it clear that many maternal autopsy reports are not as informative as they might be. This is, in part at least, because no pathologist who does not work in a maternity unit can expect to see more than a handful of such deaths in a working
D I, Rushton, I M, Dawson
openaire   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source