Results 101 to 110 of about 193,799 (312)

Nutritionally Responsive PMv DAT Neurons Are Dynamically Regulated During Pubertal Transition

The FASEB Journal, Volume 39, Issue 13, 15 July 2025.
The ventral premammillary nucleus of the hypothalamus plays an essential role in the metabolic control of reproduction. Puberty brings large changes to a subpopulation of PMvLepRb cells expressing the dopamine transporter (PMvDAT). DAT gene expression is higher in prepubertal females than in adults and is regulated by leptin in prepubertal females ...
Cristina Sáenz de Miera, Nicole Bellefontaine, Marina A. Silveira, Chelsea N. Fortin, Thais T. Zampieri, Jose Donato Jr, Kevin W. Williams, Cristiano Mendes‐da‐Silva, Laura Heikkinen, Christian Broberger, Renata Frazao, Carol F. Elias   +11 more
wiley   +1 more source

Interaction of yeast eIF4G with spliceosome components Implications in pre-mRNA processing events [PDF]

, 2009
International audienceAs evidenced from mammalian cells the eukaryotic translation initiation factor eIF4G has a putative role in nuclear RNA metabolism. Here we investigate whether this role is conserved in the yeast Saccharomyces cerevisiae.
Barrass, J. David, Beggs, Jean D., Fromont-Racine, Micheline, Jacquier, Alain, Kafasla, Panagiota, Lewis, Joe, Thompson, Elizabeth   +6 more
core   +2 more sources

Histone Deacetylase 6 Brain PET in Amyotrophic Lateral Sclerosis‐Frontotemporal Spectrum Disorder

Annals of Clinical and Translational Neurology, Volume 12, Issue 7, Page 1350-1359, July 2025.
ABSTRACT Objective [18F]EKZ‐001 is a positron emission tomography (PET) tracer targeting histone deacetylase 6 (HDAC6), an enzyme responsible for intracellular transport and clearance of misfolded proteins. HDAC6 modulation is a promising treatment strategy in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS).
Greet Vanderlinden, Charles Carron, Donatienne Van Weehaeghe, Joke De Vocht, Fouke Ombelet, Pegah Masrori, Caro De Weerdt, Rebecca E. James, Lauren T. Evans, Frederick A. Schroeder, Jacob M. Hooker, Michel Koole, Janice E. Kranz, Tonya M. Gilbert, Philip Van Damme, Koen Van Laere   +15 more
wiley   +1 more source

Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study

Journal of Neuroscience, 1991
A potent, synthetic cannabinoid was radiolabeled and used to characterize and precisely localize cannabinoid receptors in slide- mounted sections of rat brain and pituitary.
M. Herkenham, Abigail K. Lynn, M.Ross Johnson, L. Melvin, B. de Costa, K. Rice   +5 more
semanticscholar   +1 more source

Repeated Clozapine Increases the Level of Serotonin 5-HT1AR Heterodimerization with 5-HT2A or Dopamine D2 Receptors in the Mouse Cortex

Frontiers in Molecular Neuroscience, 2018
G-protein–coupled receptor (GPCR) heterodimers are new targets for the treatment of schizophrenia. Dopamine D2 receptors and serotonin 5-HT1A and 5-HT2A receptors play an important role in neurotransmission and have been implicated in many human ...
Marta Szlachta, Maciej Kuśmider, Paulina Pabian, Joanna Solich, Magdalena Kolasa, Dariusz Żurawek, Marta Dziedzicka-Wasylewska, Agata Faron-Górecka   +7 more
doaj   +1 more source

UV micro-irradiation of the Chinese hamster cell nucleus and caffeine post-treatment immunocytochemical localization of DNA photolesions in cells with partial and generalized chromosome shattering [PDF]

, 1983
UV micro-irradiation of a small part of the Chinese hamster nucleus and caffeine post-incubation often results in shattered chromosomes at the first post-irradiation mitosis.
Cornelis, Cornelis, Cornelis, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Deaven, Fukuda, Gray, Hsu, Kihlman, Lehmann, Nilsson, Stack, Stubblefield, Taylor, Zorn, Zorn   +26 more
core   +1 more source

Localization of Antigens by Autoradiography.

Experimental Biology and Medicine, 1961
SummaryAnalyses of the distribution of isotopically labeled antigens in the animal were combined with autoradiography of the tissues. After intravenous injection of heavily substituted S35-sulfanilazo-bovine γ-globulin into mice, we found protein-bound S35 in the cytoplasm of the Kupffer cells of the liver.
Martha Dicks, H. F. Cheng, Audrey N. Roberts, Felix Haurowitz, E. S. Brown, R. H. Shellhamer   +5 more
openaire   +3 more sources

Emerging Therapeutic Strategies for Hearing Loss

Advanced Therapeutics, Volume 8, Issue 7, July 2025.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han, Tian Shen, Weiwei He, Hao Wei, Xiaolong Zhao, Wen Yang, Chuan Bu, Xinghua Tang, Yu Zhao, Jiangang Fan   +9 more
wiley   +1 more source

Studies on the Quantitative Autoradiography. I. Radioluminography for Quantitative Autoradiography of 14C.

Biological and Pharmaceutical Bulletin, 1995
The process of obtaining 3H-autoradiographic (ARG) images has been expected for a long time. A few X-ray films with no protection layer are commercially available, however, they do not give a reliable image which can be quantitated and can give good contrast.
Naomi Motoji, Junji Miyahara, Seiji Tazaki, Emiko Hayama, Nobufumi Mori, Akiyo Shigematsu   +5 more
openaire   +6 more sources

Serotonin Receptors in Areas of the Emotion Regulation Network in Human and Rat Brains—A Comparative Autoradiographic Study

Journal of Comparative Neurology, Volume 533, Issue 7, July 2025.
Serotonin receptors in areas of the emotion regulation network in human and rat brains a comparative autoradiographic study. Our systematic comparative analysis revealed significant differences of 5‐HT1A and 5‐HT2 receptor distributions and of their balance within and across components of the human emotion regulation network and homolog areas in rats ...
Anika Kuckertz, Ling Zhao, Olga Kedo, Katrin Amunts, Nicola PalomeroGallagher   +4 more
wiley   +1 more source