Results 111 to 120 of about 110,609 (237)

Ecopipam, a Dopamine D1 Receptor Antagonist: Pharmacokinetics, Mass Balance, and Metabolism in Healthy Volunteers

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Ecopipam is a dopamine‐1 (D1) receptor antagonist in development for Tourette syndrome. In vitro data showed that ecopipam is metabolized to ecopipam glucuronide through uridine diphosphate‐glucuronosyltransferase 1A9 and to EBS‐101‐40853 (previously called N‐desmethylecopipam or SCH 40853) through cytochrome P450 3A4.
Virginia D. Schmith, Stephen English, Angela Dymond, Catherine Holdsworth, Ruth Stow, Emma Holbrook, Joy Schleyer, Stephen P. Wanaski   +7 more
wiley   +1 more source

Characterization of oxytocin and vasopressin receptors in the Southern giant pouched rat and comparison to other rodents

Frontiers in Endocrinology
Vasopressin and oxytocin are well known and evolutionarily ancient modulators of social behavior. The distribution and relative densities of vasopressin and oxytocin receptors are known to modulate the sensitivity to these signaling molecules ...
Angela R. Freeman, Angela R. Freeman, Samanta Arenas, Danielle N. Lee, Danielle N. Lee, Bhupinder Singh, Bhupinder Singh, Alexander G. Ophir   +7 more
doaj   +1 more source

The ribosome‐associated complex regulates cytosolic translation upon mitoprotein‐induced stress

The FEBS Journal, Volume 293, Issue 11, Page 3211-3227, June 2026.
Defects in mitochondrial protein import trigger a stress response. The contribution of translation regulation to such a response is only partially understood. We demonstrate that the deletion of mitochondrial surface proteins (TOM70/TOM71) leads to defects in mitochondrial biogenesis and slow growth.
Jiaxin Qian, Annika Nutz, Katja Hansen, Lea Bertgen, Mirita Franz‐Wachtel, Boris Macek, Johannes M. Herrmann, Doron Rapaport   +7 more
wiley   +1 more source

SENSITIVITY IN ELECTRON MICROSCOPE AUTORADIOGRAPHY II. EFFECT OF HEAVY METAL STAINING

, 1973
In quantitative electron microscopic autoradiography test specimens for sensitivity usually consist of plastic or protein films 500-1000 Å in thickness.
MIRIAM M. SALPETER
core   +1 more source

In vitro characterization of [125I]HY-3-24, a selective ligand for the dopamine D3 receptor

Frontiers in Neuroscience
IntroductionDopamine D3 receptor (D3R) ligands have been studied for the possible treatment of neurological and neuropsychiatric disorders. However, selective D3R radioligands for in vitro binding studies have been challenging to identify due to the high
Ji Youn Lee, Ho Young Kim, Paul Martorano, Aladdin Riad, Michelle Taylor, Robert R. Luedtke, Robert H. Mach   +6 more
doaj   +1 more source

Coenzyme A mitigates cystine‐deprivation‐induced ferroptosis by suppressing the iron‐starvation response

The FEBS Journal, Volume 293, Issue 11, Page 3288-3302, June 2026.
Cystine (Cys2) deprivation in pancreatic cancer cells induces oxidative stress that destabilizes cytosolic iron–sulfur cluster (ISC) proteins, triggering an iron‐regulatory protein (IRP)‐mediated iron‐starvation response (ISR). This leads to increased iron uptake (via TFRC), an expanded labile iron pool, and ferroptosis.
Mingjun Tan, Yunzhan Li, Lei Sang, Min Wang, Qin Li, Zekun Li, Dongxiao Sun, Xiuchao Wang, Shengyu Yang   +8 more
wiley   +1 more source

Co‐pathologies and biological processes beyond amyloid‐beta and tau in people with Alzheimer's disease: Evidence from clinical cohort studies

Journal of Internal Medicine, Volume 299, Issue 6, Page 694-710, June 2026.
Abstract Alzheimer's disease (AD) is neuropathologically defined by amyloid‐beta (Aβ) plaques and tau neurofibrillary tangles. However, co‐pathologies and other pathobiological processes are involved in the pathogenesis of AD, contributing to neurodegeneration and clinical symptoms.
Daniel Ferreira, Tomasz Chmiela, Maria Eriksdotter, Clifford R. Jack Jr., Grégoria Kalpouzos, Anna Marseglia, Patrizia Mecocci, Agneta Nordberg, Dorota Religa, Eric Westman   +9 more
wiley   +1 more source

Back to back autoradiography: a method for ultrastructural analysis of light microscopic autoradiographs.

, 1980
A method for studying radiolabeled cells is described that combines the simplicity of light microscopic autoradiography with the high resolution of electron microscopy.
J S Brody, N B Kaplan, L J Smith
core   +1 more source

LsMAPK6 Phosphorylates the LsCO Protein to Enhance Its Stability and Transcriptional Activity, Promoting Floral Transition Upon High Temperatures in Lettuce

Plant Biotechnology Journal, Volume 24, Issue 6, Page 4064-4083, June 2026.
ABSTRACT High temperatures significantly accelerate the timing of floral transition, namely, bolting and flowering, in lettuce, which results in severe loss of marketable yield. Thus, understanding the genetic regulation of floral transition is of great interest to plant biologists and lettuce breeders.
Tingzhen Wang, Mingjia Liu, Yufeng Tian, Qingqing Tan, Jiaxuan Wang, Huifang Mu, Chaojie Liu, Huiyu Wang, Ning Liu, Yingyan Han, Jinghong Hao   +10 more
wiley   +1 more source

[¹²⁵I]IPC-Lecanemab: Synthesis and Evaluation of Aβ-Plaque-Binding Antibody and Comparison with Small-Molecule [¹⁸F]Flotaza and [¹²⁵I]IBETA in Postmortem Human Alzheimer’s Disease

Neurology International
Therapeutic antibodies for reducing Aβ plaque load in Alzheimer’s disease (AD) is currently making rapid progress. The diagnostic imaging of Aβ plaque load in AD has been underway and is now used in clinical studies.
Christopher Liang, Cayz G. Paclibar, Noresa L. Gonzaga, Stephanie A. Sison, Harman S. Bath, Agnes P. Biju, Jogeshwar Mukherjee   +6 more
doaj   +1 more source