Results 121 to 130 of about 36,307 (249)

Sleep apnea in REM sleep as an amplifier of vascular contributions to Alzheimer's disease

open access: yesAlzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract Obstructive sleep apnea (OSA), a common though underdiagnosed disorder in older adults, represents a potential upstream vascular stressor linked to increased Alzheimer's disease (AD) risk. In this Perspective article, we propose a stage‐informed framework in which rapid eye movement (REM) sleep‐related respiratory events amplify vascular ...
Destiny E. Berisha   +2 more
wiley   +1 more source

Evaluation of Uliginosin B as a Modulator of the Ras Pathway: In Vivo Evidence From Caenorhabditis elegans and In Silico Insights

open access: yesChemistry &Biodiversity, Volume 23, Issue 8, August 2026.
This study performs in vivo and in silico assays with uliginosin B, targeting its activity in the Ras signaling pathway, demonstrating a possible allosteric interaction with the HRAS (human) and LET‐60 (nematode) proteins, and a decrease in the overexpression of the let‐60 gene in the nematode C. elegans.
Maria Eduarda O. De Souza   +9 more
wiley   +1 more source

Cerebral blood flow autoregulation during prehospital post-resuscitation care. [PDF]

open access: yesResusc Plus
Heikkilä E   +8 more
europepmc   +1 more source

A Closed‐Loop Cardiovascular Model of the Supine‐To‐Stand Manoeuvre: Implications for Falls

open access: yesInternational Journal for Numerical Methods in Biomedical Engineering, Volume 42, Issue 8, August 2026.
Continuous beat‐to‐beat modeling of supine‐to‐stand hemodynamics in older adults reproduces orthostatic responses and reveals differences in baroreflex, muscle‐pressure, and blood volume in those with a fall history, providing a basis for mechanistic phenotyping to enhance orthostatic hypotension diagnosis.
Joeri A. van de Sande   +7 more
wiley   +1 more source

Altered MicroRNA Signatures in Circulating Extracellular Vesicles Reflect Aortic Dilation in Takayasu Arteritis

open access: yesJournal of Extracellular Biology, Volume 5, Issue 8, August 2026.
ABSTRACT Takayasu arteritis (TAK) is a large‐vessel vasculitis that can lead to aneurysmal dilation, yet reliable circulating biomarkers for vascular remodelling remain lacking. Extracellular vesicles (EVs) carry miRNAs implicated in vascular biology, but their relevance to TAK has not been fully explored. Circulating EVs were isolated from serum of 54
Kohei Kawajiri   +3 more
wiley   +1 more source

De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence

open access: yesMicrobiologyOpen, Volume 15, Issue 4, August 2026.
Bacterial pathogens survive in different host environments by switching between making nucleotides by de novo synthesis and scavenging them from the host. This flexibility supports growth and virulence making nucleotide metabolism an attractive therapeutic target.
Riya Joshi   +2 more
wiley   +1 more source

Unpacking the blood flow restriction device features literature: autoregulation

open access: yesFrontiers in Sports and Active Living
Nicholas Rolnick   +2 more
doaj   +1 more source

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