Sleep apnea in REM sleep as an amplifier of vascular contributions to Alzheimer's disease
Abstract Obstructive sleep apnea (OSA), a common though underdiagnosed disorder in older adults, represents a potential upstream vascular stressor linked to increased Alzheimer's disease (AD) risk. In this Perspective article, we propose a stage‐informed framework in which rapid eye movement (REM) sleep‐related respiratory events amplify vascular ...
Destiny E. Berisha +2 more
wiley +1 more source
Integrative regulation of cerebral blood flow in response to exercise and environmental extremes
Experimental Physiology, EarlyView.
Shigehiko Ogoh, Damian M. Bailey
wiley +1 more source
This study performs in vivo and in silico assays with uliginosin B, targeting its activity in the Ras signaling pathway, demonstrating a possible allosteric interaction with the HRAS (human) and LET‐60 (nematode) proteins, and a decrease in the overexpression of the let‐60 gene in the nematode C. elegans.
Maria Eduarda O. De Souza +9 more
wiley +1 more source
Cerebral blood flow autoregulation during prehospital post-resuscitation care. [PDF]
Heikkilä E +8 more
europepmc +1 more source
A Closed‐Loop Cardiovascular Model of the Supine‐To‐Stand Manoeuvre: Implications for Falls
Continuous beat‐to‐beat modeling of supine‐to‐stand hemodynamics in older adults reproduces orthostatic responses and reveals differences in baroreflex, muscle‐pressure, and blood volume in those with a fall history, providing a basis for mechanistic phenotyping to enhance orthostatic hypotension diagnosis.
Joeri A. van de Sande +7 more
wiley +1 more source
Autoregulation of three yeast ribosomal protein genes by splicing inhibition. [PDF]
Granas D +3 more
europepmc +1 more source
ABSTRACT Takayasu arteritis (TAK) is a large‐vessel vasculitis that can lead to aneurysmal dilation, yet reliable circulating biomarkers for vascular remodelling remain lacking. Extracellular vesicles (EVs) carry miRNAs implicated in vascular biology, but their relevance to TAK has not been fully explored. Circulating EVs were isolated from serum of 54
Kohei Kawajiri +3 more
wiley +1 more source
High systolic blood pressure variability is associated with impaired cerebral autoregulation and poor functional recovery after intracerebral hemorrhage. [PDF]
Wan L, Huang G, Wu R, Wu C.
europepmc +1 more source
De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence
Bacterial pathogens survive in different host environments by switching between making nucleotides by de novo synthesis and scavenging them from the host. This flexibility supports growth and virulence making nucleotide metabolism an attractive therapeutic target.
Riya Joshi +2 more
wiley +1 more source
Unpacking the blood flow restriction device features literature: autoregulation
Nicholas Rolnick +2 more
doaj +1 more source

