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Surgical Management of Autosomal Dominant Polycystic Kidney Disease: Principles and Current Practice
Autosomal dominant polycystic kidney disease is the third most common cause of renal failure with no definitive treatment available that can directly target the development and growth of the cysts.
Badri Man Shrestha
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TAMEing ADPKD with metformin:safe and effective? [PDF]
The biguanide metformin has been safely and widely used in the treatment of type 2 diabetes mellitus for decades. Preclinical studies have suggested that it may have a role in slowing disease progression in autosomal dominant polycystic kidney disease ...
Gansevoort, Ron T, Ong, Albert C M
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Autosomal dominant polycystic kidney disease [PDF]
Mutations in PKD1 or PKD2 cause autosomal dominant polycystic kidney disease, which proceeds to kidney failure in 70% of patients between the fourth and seventh decade of life.[1][1] Signs of autosomal dominant polycystic kidney disease (i.e., numerous cysts and enlargement of the kidneys) may ...
Matthew B. Lanktree, Arlene B Chapman
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Polycystic Liver Disease: A Case Report
Polycystic liver disease is characterized by multiple cystic lesions on the liver. Liver cysts are typically incidental findings, with occasional complications including cyst hemorrhage, infection and rupture.
Randy Adiwinata+10 more
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Autosomal Dominant Polycystic Kidney Disease
Schwenger Vedat, Zeier Martin
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Autosomal dominant polycystic kidney disease [PDF]
When the BMJ last published an editorial on adult autosomal dominant polycystic kidney disease1 there was no chromosomal assignment for the disorder. Two have since been recognised. The first, designated PKD-1,2 has been localised to a narrow region of about half a million base pairs on the short arm of chromosome 16, but the specific gene has not yet ...
A K Saggar-Malik+2 more
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Molecular Mechanisms of Isolated Polycystic Liver Diseases
Polycystic liver disease (PLD) is a rare autosomal dominant disorder including two genetically and clinically distinct forms: autosomal dominant polycystic kidney disease (ADPKD) and isolated polycystic liver disease (PCLD).
Ziqi Yu+5 more
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Autosomal dominant polycystic kidney disease [PDF]
Autosomal dominant polycystic kiney disease is a hereditary systemic disorder, characterized by the developement of cysts, mainly in the kidney and liver, also with gastrointestinal and cardiovascular abnormalities. It affects 4 to 6 million people wordwide and accounts for end-stage renal disease in 7-10% of dialysis patients.
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Autosomal dominant polycystic kidney disease [PDF]
Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disease with a prevalence of 1:400 to 1:1,000 live births.[1][1] It is the most common genetic cause of renal failure, accounting for 10% of patients on dialysis.
Chern Li Chow, Albert C.M. Ong
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Management of Pain in Autosomal Dominant Polycystic Kidney Disease and Anatomy of Renal Innervation [PDF]
Purpose Chronic pain is a prominent feature of autosomal dominant polycystic kidney disease that is difficult to treat and manage, often resulting in a decrease in quality of life.
Bacallao, Robert L.+4 more
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