Results 11 to 20 of about 46,029 (270)

Management of Pain in Autosomal Dominant Polycystic Kidney Disease and Anatomy of Renal Innervation [PDF]

, 2014
Purpose Chronic pain is a prominent feature of autosomal dominant polycystic kidney disease that is difficult to treat and manage, often resulting in a decrease in quality of life.
Matthew W. Tellman, Clinton D. Bahler, Ashley M. Shumate, Robert L. Bacallao, Chandru P. Sundaram   +4 more
openalex   +4 more sources

Dual mTOR/PI3K inhibition limits PI3K-dependent pathways activated upon mTOR inhibition in autosomal dominant polycystic kidney disease [PDF]

, 2018
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the development of kidney cysts leading to kidney failure in adulthood. Inhibition of mammalian target of rapamycin (mTOR) slows polycystic kidney disease (PKD) progression in ...
Arcaro, Alexandre, Castelletti, Deborah, Fu, Xuebin, Liu, Yang, Mischak, Harald, Mullen, William, Pejchinovski, Martin, Serra, Andreas L., Siwy, Justyna, Wang, Xueqi, Watnick, Terry J.   +10 more
core   +2 more sources

Autosomal dominant polycystic kidney disease.

Clinical medicine (London), 2018
Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disease with a prevalence of 1:400 to 1:1,000 live births.[1][1] It is the most common genetic cause of renal failure, accounting for 10% of patients on dialysis.
Ch Chow, A. Ong
semanticscholar   +1 more source

Cystic Kidney Diseases That Require a Differential Diagnosis from Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Journal of Clinical Medicine, 2022
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary cystic kidney disease, with patients often having a positive family history that is characterized by a similar phenotype. However, in atypical cases, particularly those in
Akinari Sekine, S. Hidaka, T. Moriyama, Yasuto Shikida, Keiji Shimazu, E. Ishikawa, K. Uchiyama, H. Kataoka, Haruna Kawano, Mahiro Kurashige, Mai Sato, Tatsuya Suwabe, S. Nakatani, T. Otsuka, H. Kai, K. Katayama, S. Makabe, S. Manabe, Wataru Shimabukuro, K. Nakanishi, Saori Nishio, Fumihiko Hattanda, K. Hanaoka, K. Miura, H. Hayashi, J. Hoshino, K. Tsuchiya, T. Mochizuki, S. Horie, I. Narita, S. Muto   +30 more
semanticscholar   +1 more source

Polycystic Kidney Disease Drug Development: A Conference Report

Kidney Medicine, 2023
Autosomal dominant polycystic kidney disease (ADPKD) is part of a spectrum of inherited diseases that also includes autosomal recessive polycystic kidney disease, autosomal dominant polycystic liver disease, and an expanding group of recessively ...
Max C. Liebau, Djalila Mekahli, Ronald Perrone, Belle Soyfer, Sorin Fedeles   +4 more
doaj   +1 more source

An update on the use of tolvaptan for autosomal dominant polycystic kidney disease: consensus statement on behalf of the ERA Working Group on Inherited Kidney Disorders, the European Rare Kidney Disease Reference Network and Polycystic Kidney Disease International

Nephrology, Dialysis and Transplantation, 2021
Approval of the vasopressin V2 receptor antagonist tolvaptan—based on the landmark TEMPO 3:4 trial—marked a transformation in the management of autosomal dominant polycystic kidney disease (ADPKD). This development has advanced patient care in ADPKD from
R. Müller, A. L. Messchendorp, H. Birn, G. Capasso, E. Gall, O. Devuyst, A. V. van Eerde, Patrick Guirchon, T. Harris, E. Hoorn, N. Knoers, U. Korst, D. Mekahli, Y. Meur, Tom Nijenhuis, A. Ong, J. Sayer, F. Schaefer, A. Servais, V. Tesar, R. Torra, S. Walsh, R. Gansevoort   +22 more
semanticscholar   +1 more source

Ferroptosis Promotes Cyst Growth in Autosomal Dominant Polycystic Kidney Disease Mouse Models

Journal of the American Society of Nephrology, 2021
Significance Statement This study demonstrates for the first time a role of ferroptosis in ADPKD. We show the Pkd1 mutation makes renal epithelial cells prone to ferroptosis through the dysregulation of iron and lipid metabolism.
Xiao-qin Zhang, L. X. Li, Hao Ding, V. Torres, Chen Yu, Xiaogang Li   +5 more
semanticscholar   +1 more source

Urinary proteomics using capillary electrophoresis coupled to mass spectrometry for diagnosis and prognosis in kidney diseases [PDF]

, 2016
Purpose of review: Urine is the most useful of body fluids for biomarker research. Therefore, we have focused on urinary proteomics, using capillary electrophoresis coupled to mass spectrometry, to investigate kidney diseases in recent years.
Magalhães, Pedro, Mischak, Harald, Zürbig, Petra   +2 more
core   +1 more source

Extracellular vesicles and exosomes generated from cystic renal epithelial cells promote cyst growth in autosomal dominant polycystic kidney disease

Nature Communications, 2021
Autosomal dominant polycystic kidney disease (ADPKD) is caused by germline mutations of PKD1 or PKD2 on one allele and a somatic mutation inactivating the remaining normal allele.
Hao Ding, L. X. Li, P. Harris, Junwei Yang, Xiaogang Li   +4 more
semanticscholar   +1 more source

An Unusual Cardiac Manifestation in Autosomal Dominant Polycystic Kidney Disease

Case Reports in Nephrology, 2012
Autosomal dominant polycystic kidney disease is a common hereditary disorder characterized by renal and extrarenal, cystic and noncystic manifestations. Connective tissue defects, including cerebral aneurysm, meningeal diverticula, abdominal wall hernias,
Fausta Catapano, Stefano Pancaldi, Carlo Pace Napoleone, Lucia Barbara De Sanctis, Gaetano Gargiulo, Giuseppe Emiliani, Antonio Santoro   +6 more
doaj   +1 more source