Results 21 to 30 of about 43,436 (236)

Molecular Mechanisms of Isolated Polycystic Liver Diseases

Frontiers in Genetics, 2022
Polycystic liver disease (PLD) is a rare autosomal dominant disorder including two genetically and clinically distinct forms: autosomal dominant polycystic kidney disease (ADPKD) and isolated polycystic liver disease (PCLD).
Ziqi Yu, Xiang Shen, Chong Hu, Jun Zeng, Aiyao Wang, Jianyong Chen   +5 more
doaj   +1 more source

Autosomal dominant polycystic kidney disease [PDF]

Clinical Medicine, 2009
Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disease with a prevalence of 1:400 to 1:1,000 live births.[1][1] It is the most common genetic cause of renal failure, accounting for 10% of patients on dialysis.
Chern Li, Chow, Albert C M, Ong
openaire   +2 more sources

Advances in Autosomal Dominant Polycystic Kidney Disease: A Clinical Review

Kidney Medicine, 2020
Polycystic kidney disease (PKD) is a multiorgan disorder resulting in fluid-filled cyst formation in the kidneys and other systems. The replacement of kidney parenchyma with an ever-increasing volume of cysts eventually leads to kidney failure. Recently,
Niloofar Nobakht, Ramy M. Hanna, Maha Al-Baghdadi, Khalid Mohammed Ameen, Farid Arman, Ehsan Nobahkt, Mohammad Kamgar, Anjay Rastogi   +7 more
doaj   +1 more source

A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery.

Cell Stem Cell, 2022
Human pluripotent stem-cell-derived organoids are models for human development and disease. We report a modified human kidney organoid system that generates thousands of similar organoids, each consisting of 1-2 nephron-like structures.
Tracy Tran, C. Song, Trang T.T. Nguyen, Shun-Yang Cheng, J. McMahon, Rui Yang, Qiuyu Guo, Bálint Dér, N. Lindström, Daniel C.-H. Lin, Andrew P. McMahon   +10 more
semanticscholar   +1 more source

Exome Sequencing of a Clinical Population for Autosomal Dominant Polycystic Kidney Disease.

Journal of the American Medical Association (JAMA), 2022
Importance Most studies of autosomal dominant polycystic kidney disease (ADPKD) genetics have used kidney specialty cohorts, focusing on PKD1 and PKD2.
Alexander R. Chang, B. Moore, Jonathan Z. Luo, G. Sartori, Brian Fang, Steven Jacobs, Yoosif Abdalla, Mohammed Taher, D. Carey, William J Triffo, Gurmukteshwar Singh, T. Mirshahi   +11 more
semanticscholar   +1 more source

Severe autosomal dominant polycystic kidney disease [PDF]

BMJ Case Reports, 2018
A 61-year-old man with a known history of autosomal dominant polycystic kidney disease (ADPKD) and stage IV chronic kidney disease presented with a 6-month history of abdominal pain, nausea, vomiting and fatigue. In addition to the ADPKD, the right kidney had a 4.4 cm inferior pole mass concerning for renal cell carcinoma (RCC).
Neal S Gerstein, Craig E Rumbaugh, Julie M Riley   +2 more
openaire   +2 more sources

Management of Pain in Autosomal Dominant Polycystic Kidney Disease and Anatomy of Renal Innervation [PDF]

, 2015
Purpose Chronic pain is a prominent feature of autosomal dominant polycystic kidney disease that is difficult to treat and manage, often resulting in a decrease in quality of life.
Bacallao, Robert L., Bahler, Clinton D., Shumate, Ashley M., Sundaram, Chandru P., Tellman, Matthew W.   +4 more
core   +1 more source

Autosomal Dominant Polycystic Kidney Disease: From Pathophysiology of Cystogenesis to Advances in the Treatment

International Journal of Molecular Sciences, 2022
Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic renal disease, with an estimated prevalence between 1:1000 and 1:2500. It is mostly caused by mutations of the PKD1 and PKD2 genes encoding polycystin 1 (PC1) and polycystin ...
J. Reiterová, V. Tesar
semanticscholar   +1 more source

Autosomal dominant polycystic kidney disease with diffuse proliferative glomerulonephritis - an unusual association: a case report and review of the literature

Journal of Medical Case Reports, 2010
Introduction Autosomal dominant polycystic kidney disease is an inherited disorder that is characterized by the development and growth of cysts in the kidneys and other organs.
Kapoor Vinay, Minz Ranjana, Kaur Ravinder, Mohan Harsh, Singh Rajdeep, D'Cruz Sanjay, Sachdev Atul   +6 more
doaj   +1 more source

Vasopressin regulates the growth of the biliary epithelium in polycystic liver disease [PDF]

, 2016
The neurohypophysial hormone arginine vasopressin (AVP) acts by three distinct receptor subtypes: V1a, V1b, and V2. In the liver, AVP is involved in ureogenesis, glycogenolysis, neoglucogenesis and regeneration. No data exist about the presence of AVP in
Alpini, Gianfranco, Carpino, Guido, Franchitto, Antonio, Gaudio, Eugenio, Glaser, Shannon, Mancinelli, Romina, Olivero, Francesca, Onori, Paolo, Pannarale, Luigi, Sferra, Roberta, Venter, Julie, Vetuschi, Antonella   +11 more
core   +1 more source