Results 61 to 70 of about 149,259 (318)

Insulin-like growth factor-1 induces hyperproliferation of PKD1 cystic cells via a Ras/Raf dependent signalling pathway [PDF]

, 2007
Autosomal dominant polycystic kidney disease (ADPKD) largely results from mutations in the PKD1 gene leading to hyperproliferation of renal tubular epithelial cells and consequent cyst formation.
Harris, P.C., Newby, L.J., O'Hare, O.J., Ong, A.C.M., Parker, E., Rossetti, S., Sharpe, C.C., Streets, A.J.   +7 more
core   +1 more source

Hypertension in autosomal dominant polycystic kidney disease

Kidney International, 1988
Autosomal dominant polycystic kidney disease (ADPKD) has been shown to be associated with a greater than 50 percent incidence of hypertension prior to deterioration in renal function as assessed by glomerular filtration rate. The present study provides evidence for increased cardiac pre-load, as assessed by plasma atrial natriuretic factor (ANF) and ...
Patricia E. Bell, Ann M. Johnson, Jacques A. Durr, Patricia A. Gabow, Kenneth F. Hossack, Robert W. Schrier   +5 more
openaire   +3 more sources

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Renal cysts in children: a single centre study

Pediatria i Medycyna Rodzinna, 2018
Kidney cysts may be congenital (associated or not with genetic disorders) or rarely acquired. They may be an isolated abnormality or be part of an anomaly syndrome.
Anna Medyńska, Konstancja Fornalczyk, Katarzyna Kiliś-Pstrusińska, Irena Wikiera-Magott, Dominik Kubicki, Danuta Zwolińska   +5 more
doaj   +1 more source

The PROPKD Score: A New Algorithm to Predict Renal Survival in Autosomal Dominant Polycystic Kidney Disease.

Journal of the American Society of Nephrology, 2016
The course of autosomal dominant polycystic kidney disease (ADPKD) varies among individuals, with some reaching ESRD before 40 years of age and others never requiring RRT.
E. Cornec-Le Gall, M. Audrézet, A. Rousseau, M. Hourmant, É. Renaudineau, C. Charasse, M. Morin, M. Moal, J. Dantal, B. Wehbe, R. Perrichot, T. Frouget, C. Vigneau, J. Potier, P. Jousset, M. Guillodo, P. Siohan, N. Terki, T. Sawadogo, D. Legrand, V. Menoyo-Calonge, S. Benarbia, D. Besnier, H. Longuet, C. Férec, Y. Le Meur   +25 more
semanticscholar   +1 more source

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

Advanced Science, EarlyView.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang, Xiaofan Zhu, Zhenzhou Huang, Kaidi Ren, Jie Ran, Yang Yang   +5 more
wiley   +1 more source

Advances in Autosomal Dominant Polycystic Kidney Disease: A Clinical Review

Kidney Medicine, 2020
Polycystic kidney disease (PKD) is a multiorgan disorder resulting in fluid-filled cyst formation in the kidneys and other systems. The replacement of kidney parenchyma with an ever-increasing volume of cysts eventually leads to kidney failure. Recently,
Niloofar Nobakht, Ramy M. Hanna, Maha Al-Baghdadi, Khalid Mohammed Ameen, Farid Arman, Ehsan Nobahkt, Mohammad Kamgar, Anjay Rastogi   +7 more
doaj  

Incidental renal cell carcinoma presenting in a renal transplant recipient with autosomal dominant polycystic kidney disease: a case report

Journal of Medical Case Reports, 2012
Introduction We report an instructive case of incidental renal cell carcinoma in a patient with autosomal dominant polycystic kidney disease who underwent simultaneous bilateral native nephrectomy and living donor renal transplantation. Case presentation
Misumi Toshihiro, Ide Kentaro, Onoe Takashi, Banshodani Masataka, Tazawa Hirofumi, Teraoka Yoshifumi, Hotta Ryuichi, Yamashita Masahiro, Tashiro Hirotaka, Ohdan Hideki   +9 more
doaj   +1 more source

A Generic Framework for Hidden Markov Models on Biomedical Data [PDF]

arXiv, 2023
Background: Biomedical data are usually collections of longitudinal data assessed at certain points in time. Clinical observations assess the presences and severity of symptoms, which are the basis for description and modeling of disease progression.
arxiv  

Autosomal-dominant polycystic kidney disease in the rat

Kidney International, 1993
Kaspareit-Rittinghausen described a rodent model of inherited polycystic kidney disease (PKD), the Han:SPRD rat [1, 2], in which heterozygotes develop renal cysts and renal failure (in males) over several months, whereas homozygous animals develop rapidly progressive renal enlargement that leads to death in a few weeks.
H I I Vincent Gattone, Brian D. Barash, Amy L. Kraybill, Michael A. Harding, James P. Calvet, Benjamin D. Cowley, Seshagirirao Gudapaty   +6 more
openaire   +3 more sources