Results 81 to 90 of about 811,009 (286)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Population Median Estimation Using Auxiliary Variables: A Simulation Study with Real Data Across Sample Sizes and Parameters

Mathematics
This paper introduces an enhanced class of ratio estimators, which employ the transformation technique on an auxiliary variable under simple random sampling to estimate the population median.
Umer Daraz, Fatimah A. Almulhim, Mohammed Ahmed Alomair, Abdullah Mohammed Alomair   +3 more
doaj   +1 more source

Automatic Image Annotation Based on Multi-Auxiliary Information

IEEE Access, 2017
This paper introduces an automatic image annotation framework based on multi-auxiliary information which aims at improving the annotation performance. We propose three novel ideas in the framework of annotation: 1) multi-information extraction: besides ...
Pengyu Zhang, Zhihua Wei, Yunyi Li, Cairong Zhao   +3 more
doaj   +1 more source

Improving the geometric fidelity of imaging systems employing sensor arrays [PDF]

A sensor assembly to be carried on an aircraft or spacecraft which will travel along an arbitrary flight path, for providing an image of terrain over which the craft travels, is disclosed.
Jones, Kenneth L.
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Improved methods for estimation in repeated surveys: Combining time series and calibration

Nonlinear Analysis
The paper investigates new estimation techniques for repeated surveys, focusing on improving the precision of finite population parameter estimates at the current time t by incorporating auxiliary time series and calibration methods.
Dalius Pumputis
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

New Class of Estimators for Finite Population Mean Under Stratified Double Phase Sampling with Simulation and Real-Life Application

Mathematics
Sampling survey data can sometimes contain outlier observations. When the mean estimator becomes skewed due to the presence of extreme values in the sample, results can be biased. The tendency to remove outliers from sample data is common.
Abdulaziz S. Alghamdi, Hleil Alrweili
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source