Results 111 to 120 of about 105,912 (274)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Hehl, Ernst-Dieter, Gregor VII. und Heinrich IV. in Canossa 1077 (= MGH Studien und Texte 66): Wiesbaden, 2019

, 2022
Rolker, Christof
core   +1 more source

Vitebsk Secondary Special Agricultural Educational Institutions and Their Training and Auxiliary Enterprises: History of Origin, Stages of Development and Peculiarities of Liquidation (1919 – 1926)

, 2020
Излагаются причины, послужившие основанием для создания в г. Витебске после событий Октябрьской революции (1917 г.) специальных сельскохозяйственных учебных заведений, рассмотрены этапы их возникновения и реорганизация.
Bondarava, A., Буевич, Т. В., Бондарева, Е. М., Buyevich, T.   +3 more
core  

Патологические и модификационные изменения костей домашнего скота из поселений Синташта и Аркаим синташтинской культуры Южного Урала

Уфимский археологический вестник
Статья посвящена обсуждению результатов повторного исследования археозоологических коллекций поселений Синташта и Аркаим. Основное внимание было уделено анализу патологических и модификационных изменений на костях домашнего скота.
Рассадников Алексей Юрьевич
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Междисциплинарность: вызов или новые возможности для археологии?

Уфимский археологический вестник
Статья рассматривает проблемы интеграции методов разных наук в археологическое исследование и влияние этого процесса на развитие научной практики.
Епимахов Андрей Владимирович
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

On Weighted Remainder Form of Hardy-Type Inequalities

, 2009
We use different approaches to study a generalization of a result of Levin and Stečkin concerning an inequality analogous to Hardy’s inequality.
Gao, Peng
core  

Science and Reality [PDF]

, 2006
Scientific realism is the view that the aim of science is to produce true or approximately true theories about nature. It is a view which not only is shared by many philosophers but also by scientists themselves.
Faye, Jan
core  

Archival Science and Auxiliary Historical Disciplines

, 1992
Статията проследява развитието и институционализирането на катедрата „Архивистика и помощни исторически дисциплини“ в Историческия факултет на Софийския университет „Св. Климент Охридски“.
Шопов, Йордан, Shopov, Jordan, Petkova, Stefka, Петкова, Стефка   +3 more
core   +1 more source