Results 101 to 110 of about 105,912 (274)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Genealogy: an Auxiliary Science of History in Cyberspace

Rocznik Filozoficzny Ignatianum
Genealogy, as an auxiliary science of history, has been present in cyberspace for some time now, surpassing other auxiliary historical sciences in terms of online visibility. This distinction is evident even when comparing the number of views on webpages resulting from searches, indicating the popularity of genealogical research.
openaire   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Stöckly, Doris (Ed.), Bernold von Konstanz, “De excommunicatis vitandis,” “De reconciliatione lapsorum” et “De fontibus iuris ecclesiastici (libellus X)": Wiesbaden, 2018

, 2022
Rolker, Christof
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Genealogy in Croatia: Genealogy as an Auxiliary Science of History in Croatian Historiography

, 2019
Auxiliary sciences of history (palaeography, diplomatics, chronology, egdotics, sigillography, heraldry, genealogy) have a long and rich tradition within Croatian historiography. They were taught (palaeography, diplomatics) as a separate course at the Royal Academy of Sciences in Zagreb in the eighteenth century, and Ivan Kukuljević Sakcinski proposed ...
openaire   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

On the Empirical Equivalence Between Special Relativity and Lorentz's Ether Theory [PDF]

, 2013
In this paper I argue that the case of Einstein’s special relativity vs. Hendrik Lorentz’s ether theory can be decided in terms of empirical evidence, in spite of the predictive equivalence between the theories.
Acuña, Pablo
core  

The Complex Relationship Between Darwinism, Geopolitics and Geographic Colonization Research the Relationship Between Geopolitics and Ethnography

مجلة كلية التربية للبنات, 2019
Research on geopolitical and geopolitical studies relates to a range of sciences that can be called auxiliary sciences, such as political science, international relations in particular, and history, but their focus is rarely on science and ethnography
Muhaymin Abdul Halim Al – Wadi
doaj  

Каменный инвентарь энеолитического комплекса поселения Пякупур 3 (северотаежная зона Западной Сибири)

Уфимский археологический вестник
В статье дана характеристика каменной индустрии энеолитического периода обитания на поселении Пякупур 3, расположенного в северотаежной зоне Западной Сибири.
Скочина Светлана Николаевна, Пошехонова Ольга Евгеньевна   +1 more
doaj   +1 more source