Results 91 to 100 of about 105,912 (274)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Władysław Semkowicz as a founder of modern auxiliary sciences of history : reflections on the seventy-fifth anniversary of his death

Władysław Semkowicz (1878-1949) był najwybitniejszym polskim badaczem nauk pomocniczych historii, autorem skryptu-podręcznika Encyklopedia nauk pomocniczych historii, określającym polski kanon tych dyscyplin.
Piech, Zenon
core  

The history of the concept of grammaticalisation [PDF]

, 2004
The present thesis discusses the history and meaning of the term and concept called grammaticalisation. Linguists usually ascribe the coinage of the term grammaticalisation to Antoine Meillet (1866-1936), who allegedly played a vital role in the history
Lindström (Tiedemann), Therese Åsa Margaretha
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Papal Jurisprudence c. 400: Sources of the Canon Law Tradition. By David L.d’Avray. Cambridge: Cambridge University Press. 2019. 302 pp. £75. ISBN 9781108472937.Papal Jurisprudence, 385–1234: Social Origins and Medieval Reception of Canon Law. By David L.d’Avray. Cambridge: Cambridge University Press. 2022. 332 pp. £75. ISBN 9781108595292.

, 2023
Christof Rolker, Rolker, Christof
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Die zwei Dekretalenzeitalter im Vergleich : Anmerkungen zu David d’Avrays „Papal Jurisprudence“

Päpstliche Dekretalen haben eine lange Geschichte, und auch ihre Erforschung wird seit mehreren Jahrhunderten auf hohem Niveau betrieben. Die fortschreitende Spezialisierung der Forschung hat dabei bewunderswerte Ergebnisse ermöglicht, aber leider auch ...
Rolker, Christof
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

On novel facts. A discussion of criteria for non-ad-hoc-ness in the methodology of scientific research programmes

, 1988
Carrier M. On novel facts. A discussion of criteria for non-ad-hoc-ness in the methodology of scientific research programmes. Zeitschrift für allgemeine Wissenschaftstheorie.
Carrier, Martin
core   +1 more source