Results 71 to 80 of about 107,275 (234)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Prace HistoryczneIn this article, the author presents the achievements of a new palaeographic discipline known as fragmentology.
Marcin Starzyński
doaj +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Историко-географический журналThe publication includes the letters by O. M. Medushevskaya to V. K. Yatsunskiy written in 1956–1966. They are of interest to the study of the beginning of O. М. Medushevskaya’s research path, which is associated with historical geography and the history
T. K. Kholmatov
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International Journal of General Medicine, 2022 Yijin Chen,1,2,* Hongtao Liu,2,3,* Zhikang Yu,2,4 Yang Yang,1,2 Qingyan Huang,2,4 Changqing Deng,1,2 Hui Rao,2,4 Heming Wu2,4 1Department of Gastroenterology, Meizhou People’s Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences ...
Chen Y +7 more
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Pozůstalost archiváře Theodora Rosenthala
Studia Historica Brunensia, 2015 Author presents basic overview of the papers of the archivist and historian Theodor Anton Taulow von Rosenthal (1702–1779), founder and the first archivist of Home, Court and State Archives (Haus-, Hof- und Staatsarchiv) in Vienna. Rosenthal created many
Jan Kahuda
doaj