Results 71 to 80 of about 278,622 (265)
Memo, 2018 Illuminierte Urkunden erfordern als Objekte mit Text-Bild-Kombinationen einen interdisziplinären Zugang, um sie angemessen zu erforschen. Expertinnen und Experten im Feld der Kunstgeschichte, der Historischen Hilfswissenschaften – allen voran der ...
Markus Gneiß, Andreas Zajic
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Supersymmetry - Roots That Didn't Grow
, 2015 This article is about early roots of supersymmetry, as found in the literature from 1940s and early 1950s. There were models where the power of "partners" in alleviating divergences in quantum field theory was recognized.
Jarlskog, Cecilia
core +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Kontekstualność w nauczaniu literatury [PDF]
, 2002 This article contains a review of contexts used in school-didactics of literature. The definition of intertextuality, context and other theoretical problems are considered in the first chapter. Second chapter contains a review of each kind of contexts.
Zaborowska, Wiesława
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
De Dicto and De Re: A Brandomian experiment on Kierkegaard [PDF]
, 2019 During the last few decades, the historical turn within the tradition of the analytic tradition has experienced growing enthusiasm concerning the procedure of rational reconstruction, whose validity or importance, despite its paradigmatic examples in ...
Ferreira, Gabriel
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Prace HistoryczneIn the present article, the Author offers a detailed overview of the most recent history of the Departament of Auxiliary Sciences of Historical and Source Studies at the Jagiellonian University over ...
Jakub Rogulski
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source