Results 61 to 70 of about 278,622 (265)
Historiography of nursing in Spain: the story of a small-great family
Cultura de los Cuidados, 2012 The main target focuses in the way research of Nursing History allows us today to mention such a simple heading 'Historiography', if we consider the extreme rigour general History demands on analyzing different trends along centuries to deal with ...
Francisca Hernández Martín
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Cenozoic evolution of Neotethys and implications for the causes of plate motions [PDF]
, 2003 Africa-North America-Eurasia plate circuit rotations, combined with Red Sea rotations and new estimates of crustal shortening in Iran define the Cenozoic history of the Neotethyan ocean between Arabia and Eurasia. The new constraints indicate that Arabia-
McQuarrie, N. +3 more
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Prace HistoryczneBetween 1994 and 2008, a team composed of students from the Epigraphy Section of the Student Historical Society at the Jagiellonian University, doctoral candidates, and young scholars, led by Wojciech
Wojciech Drelicharz
doaj +1 more source
Teaching issues of contemporary history using historical sources and modern teaching methods
MATEC Web of Conferences, 2017 The study of history is becoming increasingly less interesting to students, despite the fact that the history teaching process has been continuously modernized during recent years.
Gruber Gabriela
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Weak Scientism Defended Once More: A Reply to Wills [PDF]
, 2018 Bernard Wills (2018) joins Christopher Brown (2017, 2018) in criticizing my defense of Weak Scientism (Mizrahi 2017a, 2017b, 2018a). Unfortunately, it seems that Wills did not read my latest defense of Weak Scientism carefully, nor does he cite any of ...
Mizrahi, Moti
core
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source