Results 121 to 130 of about 4,094,957 (302)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

A Two-Stage Deep Learning Method for Auxiliary Diagnosis of Upper Limb Fractures Based on ResNet-50 and Enhanced YOLO

Mathematics
Aiming at the problem that the existing auxiliary diagnosis methods for fractures are mostly limited to specific body parts and lack generality and robustness when applied to multi-part diagnoses, this study proposes a two-stage upper limb fracture ...
Hongxiao Wang, Zhe Li, Dingsen Zhang
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Auxiliary Signal Design for Fault Detection for Nonlinear Systems: Direct Approach

, 2008
The main task of active fault detection is to design an auxiliary signal which acting on the system will reveal to the observer a potential fault of the system.
Andjelkovic, Ivan V.
core  

Trajectory Control of a Cart-inverted Pendulum System in the Presence of a Jet Force for an Open Loop Stabilization

Journal of Engineering and Sustainable Development, 2011
This paper presents an investigation on the stabilization and the tracking problem of an inverted pendulum-cart system. An open loop subsystem is augmented to the original components which comprises an auxiliary stable pendant pendulum, (P.P.), and a ...
Zakariya Yahya Mohammad
doaj  

Evaluating Scientific Tourism of Geoheritage: An Empirical Study of Fangshan Global Geopark in Beijing

Land
Scientific tourism (ScT) of geoheritage serves as a crucial approach to ensuring the protection of natural heritage. Establishing a comprehensive evaluation system to guide the exploration of ScT in geoheritage is essential.
Zehui Zhu, Jiaming Liu, He Zhu, Wudong Zhao   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A new auxiliary function method for systems of nonlinear equations

, 2014
In this paper, we present a new global optimization method to solve nonlinear systems of equations. We reformulate given system of nonlinear equations as a global optimization problem and then give a new auxiliary function method to solve the ...
Wu, Zhiyou, Bai, Fusheng, Yang, Yongjian, Li, Guoquan   +3 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Auxiliary Density Perturbation Theory for Restricted Open-Shell Systems

, 2017
The recently developed approach to auxiliary density perturbation theory (<em>J. Chem. Phys.</em> <strong>2008</strong>, <em>128</em>, 134105) for the purpose of calculating molecular properties is here extended to ...
Francisco José Tenorio, Jaime Gustavo Rodríguez-Zavala, Roberto Flores-Moreno, Gregorio Guzmán-Ramírez   +3 more
core   +1 more source