Results 111 to 120 of about 4,094,957 (302)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
New approach to stochastic optimal control and applications to economics [PDF]
, 2005 This paper provides new insights into the solution of optimal stochastic control problems by means of a system of partial differential equations, which characterize directly the optimal control.
Rincón-Zapatero, Juan Pablo +1 more
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Auxiliary Objectives for Neural Error Detection Models
, 2017 We investigate the utility of different auxiliary objectives and training strategies within a neural sequence labeling approach to error detection in learner writing.
Marek Rei, Helen Yannakoudakis
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
A New Scalar Auxiliary Variable Approach for Gradient Flows
The scalar auxiliary variable (SAV) approach is a highly efficient method widely used for solving gradient flow systems. This approach offers several advantages, including linearity, unconditional energy stability, and ease of implementation.
Zhang, Jinpeng, Wang, Xiaoping
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, 2019 In this paper is presented the physical model and mathematical approach which describe the equation system used in system calibration and design optimization.
Mugurel Florin Talpiga +2 more
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
An Auxiliary Teaching Management System by Applying Six Sigma Method
, 2015 It has been an important issue to improve learning quality. Traditional learning process has many problems in different areas such as teaching methods, material, examinations and etc. The teacher adjusts his teaching style only according experiences that
Liou Chu
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
LOX/hydrocarbon auxiliary propulsion system study
, 1982 Liquid oxygen (LOX)/hydrocarbon propulsion concepts for a "second generation' orbiter auxiliary propulsion system was evaluated. The most attractive fuel and system design approach identified, and the technology advancements that are needed to provide ...
Orton, G. F., Weber, D. D., Mark, T. D.
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