Results 131 to 140 of about 42,339 (298)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Providing climate design solutions in hot and dry climates of Shiraz [PDF]
تحقیقات کاربردی علوم جغرافیاییThe climatic conditions of various regions in Iran are critical parameters in the design and provision of thermal comfort within residential architecture.
tara heidari orojloo +2 more
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
, 2013 Freeways operate closest to the purest form of uninterrupted traffic flow. There is no constant interruption to traffic flow (such as stop sign and traffic signal), and access is limited to ramp locations.
Wang, Yubian
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Water table mapping using Bayesian data fusion with auxiliary data
, 2010 Water table elevations are usually sampled in space using piezometric measurements, that are unfortunately both expensive to drill and monitor and consequently are thus scarce over space. Most of the time, piezometric data are sparsely distributed over large areas, thus providing limited direct information about the level of the corresponding water ...
Fasbender, Dominique +3 more
openaire +1 more source
Design and scope of impact of auxiliary lanes : technical report.
PDFTech ReportFHWA/TX-14/0-6706-1Project 0-6706Auxiliary lanesHighway designGuidelinesImplementationFreewaysImpact studiesBest practicesMicrosimulationState of the practiceSurveysRecommendationsTexasTexas. Dept. of Transportation. Research and Technology
core
Codata thermodynamic tables : the alloy system Ca-Mg
, 1987 International audienceRecommended values are presented for chemical thermodynamic properties of selected compounds of calcium and their mixtures. These have been prepared in accord with a previously developed plan and as a test of it.
Chevalier, Pierre-Yves, Ansara, Ibrahim
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source