Results 121 to 130 of about 2,583,808 (327)

On estimating quantiles using auxiliary information

, 2015
We propose a transformation-based approach for estimating quantiles using auxiliary information. The proposed estimators can be easily implemented using a regression estimator.
Yves G. Berger, Berger, Yves G., Juan F. Munoz, Francisco Munoz, Juan   +3 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Shape factor analysis of water and aluminium oxide nanoparticles in a porous medium with slip effects

Chemical Physics Impact
This article explores the flow of a nanofluid over a flat plate subjected to a magnetic field. The chosen nanofluid comprises Al₂O₃ nanoparticles mixed in water as the base fluid. Various nanoparticle shapes are analyzed to inspect fluid flow and thermal
Prasun Choudhary, K. Loganathan, Kavita Jat, Kalpna Sharma, S. Eswaramoorthi   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Разработка и систематизация алгоритмов управления электрооборудованием энергосберегающих технологических линий обработки молока

Agricultural Science, 2015
The authors have developed and systematized electrical equipment control algorithms of milk processing energy-efficient lines in this article. Control objects were divided into standard sections, electrical equipment was divided into functional units. We
ВОЛКОНОВИЧ Ливиу, КУШНИР М. Г. , ВОЛКОНОВИЧ А. Л. , СТЕОПКА О. Г., СЛИПЕНКИ В. Е., КИРИЯК И. И., ПОПА А. Г.   +6 more
doaj  

Comparing implicit boundary and hierarchical plurigaussian simulation for modeling geological domains using hard and soft data

Scientific Reports
The delineation of geological domains is a crucial step in mineral resource evaluation, as it directly influences the accuracy of grade models. Instead of a single geological interpretation, geostatistical simulation generates multiple scenarios that ...
Veronica Veliz, Jordan Plaza-Carvajal, Mohammad Maleki, Felipe Navarro, Eduardo Campos, Xavier Emery   +5 more
doaj   +1 more source

Embedding Secret Data in a Vector Quantization Codebook Using a Novel Thresholding Scheme

Mathematics
In recent decades, information security has become increasingly valued, including many aspects of privacy protection, copyright protection, and digital forensics. Therefore, many data hiding schemes have been proposed and applied to various carriers such
Yijie Lin, Jui-Chuan Liu, Ching-Chun Chang, Chin-Chen Chang   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source