Avarol Induces Apoptosis in Pancreatic Ductal Adenocarcinoma Cells by Activating PERK–eIF2α–CHOP Signaling [PDF]
Marine Drugs, 2015 Avarol is a sesquiterpenoid hydroquinone with potent cytotoxicity. Although resolving endoplasmic reticulum (ER) stress is essential for intracellular homeostasis, erratic or excessive ER stress can lead to apoptosis.
Takushi Namba, Rika Kodama
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Evaluation of In Vitro Cytotoxic Potential of Avarol towards Human Cancer Cell Lines and In Vivo Antitumor Activity in Solid Tumor Models [PDF]
Molecules, 2022 The goal of this study was to determine the activity in vitro and in vivo of avarol, a sesquiterpene hydroquinone originating from the Dysidea avara sponge from the south Adriatic Sea, against different cancer cell lines and two types of mouse carcinoma.
Tatjana P. Stanojkovic +11 more
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Investigating the Antiparasitic Potential of the Marine Sesquiterpene Avarone, Its Reduced Form Avarol, and the Novel Semisynthetic Thiazinoquinone Analogue Thiazoavarone [PDF]
Marine Drugs, 2020 The chemical analysis of the sponge Dysidea avara afforded the known sesquiterpene quinone avarone, along with its reduced form avarol. To further explore the role of the thiazinoquinone scaffold as an antiplasmodial, antileishmanial and antischistosomal
Concetta Imperatore +13 more
doaj +4 more sources
Interactions of the anti-tumor sesquiterpene hydroquinone avarol with DNA in vitro [PDF]
Journal of the Serbian Chemical Society, 2007 Changes in electrophoresis pattern after interaction of supercoiled plasmid pBR322 DNA with avarol was studied at a micromolar concentration of reactants under mild reaction conditions.
MIROSLAVA VUJCIC +4 more
doaj +8 more sources
A Review on Genotoxic and Genoprotective Effects of Biologically Active Compounds of Animal Origin [PDF]
Toxins, 2023 Envenomation by animal venoms remains a serious medical and social problem, especially in tropical countries. On the other hand, animal venoms are widely used as a source of biologically active compounds for the development of novel drugs.
Nikolajs Sjakste, Goran Gajski
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Reactivity and Biological Activity of the Marine Sesquiterpene Hydroquinone Avarol and Related Compounds from Sponges of the Order Dictyoceratida [PDF]
Molecules, 2006 A review of results of bioactivity and reactivity examinations of marine sesquiterpene (hydro)quinones is presented. The article is focused mostly on friedo- rearranged drimane structural types, isolated from sponges of the order Dictyoceratida. Examples
Miroslav J. Gasic, Dusan Sladic
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Evaluation of the Activity of the Sponge Metabolites Avarol and Avarone and their Synthetic Derivatives Against Fouling Micro- and Macroorganisms [PDF]
Molecules, 2007 The sesquiterpene hydroquinone avarol (1) was isolated from the marine sponge Dysidea avara, whereas the corresponding quinone, avarone (2), was obtained by oxidation of avarol, and the significantly more lipophilic compounds [3’-(p-chloro-phenyl)avarone
Maria Tsoukatou +9 more
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Marine Sponge is a Promising Natural Source of Anti-SARS-CoV-2 Scaffold [PDF]
Frontiers in Pharmacology, 2021 The current pandemic caused by SARS-CoV2 and named COVID-19 urgent the need for novel lead antiviral drugs. Recently, United States Food and Drug Administration (FDA) approved the use of remdesivir as anti-SARS-CoV-2.
Alshaimaa M. Hamoda +12 more
doaj +2 more sources
Induction of γ‐Interferon by Avarol in Human Peripheral Blood Lymphocytes [PDF]
Japanese Journal of Cancer Research, 1988 Avarol is a cytostatic and anti‐human immunodeficiency virus (HIV) agent. In this study, the avarol caused induction of γ‐interferon (IFN‐γ) in buffy coat cells (human peripheral blood lymphocytes) is demonstrated by immunological and molecular biological techniques.
Rita Voth +8 more
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Sources of Secondary Metabolite Variation in Dysidea avara (Porifera: Demospongiae): The Importance of Having Good Neighbors [PDF]
Marine Drugs, 2013 Several studies report temporal, geographical, and intra-individual variation in sponge metabolite yields. However, the internal and/or external factors that regulate the metabolite production remain poorly understood.
Bernard Banaigs +5 more
doaj +2 more sources