Results 91 to 100 of about 346 (137)
ChemInform Abstract: Studies on Avarol Derivatives. 2′,5′‐Diacetylavarol from Dysidea avara.
The X-ray analysis of the natural product 2',5'-di-acetylavarol [De Giulio, De Rosa, Di Vincenzo & Strazzullo (1990). Tetrahedron, 46, 7971-7976], 2-[(1,2,3,4,4a,7,8,8a-octahydro-1,2,4a,5-tetrarnethyl-1 -naphthyl)methyl]-1,4-benzenediyl diacetate, C 25 H 34 O 4 , is reported.
R. Puliti +2 more
+5 more sources
Antimutagenic activity of the novel antileukemic agents, avarone and avarol
The two antileukemic agents, avarone and avarol, were determined to be neither direct nor indirect mutagenic agents in the Ames microsomal test. Moreover, the two sesquiterpenoid compounds drastically reduced the mutagenic effect of benzo[a]pyrene in the same system.
B. Kureleć +5 more
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ChemInform Abstract: Enantioselective Total Synthesis of Avarol and Avarone.
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Taotao Ling +2 more
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Enantiospecific total synthesis of (+)- and (–)-avarone and -avarol
Enantiopure avarol and its oxidized congener avarone are synthesized in both podal series from an optically pure Wieland–Miescher enone; preliminary results from biochemical studies are summarized.
Edward P. Locke, Sidney M. Hecht
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Effect of avarol and avarone on in vitro-induced microsomal lipid peroxidation
Lipid peroxidation was employed as an experimental model to study the antioxidant properties of avarol, a sesquiterpenoid hydroquinone and of its quinone, avarone. In the NADPH- or ascorbate-linked lipid peroxidation, avarol and avarone were shown to be more effective as inhibitors than in the t-BuOOH-dependent peroxidative process.
Maria Antonietta Belisario +4 more
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Avarol and avarone, two new anti-inflammatory agents of marine origin
The anti-inflammatory activity of avarol and avarone, sesquiterpenoid derivatives from the Mediterranean sponge Dysidea avara, was investigated. Both compounds potently inhibited paw oedema induced by carrageenan (approximated ED50 = 9.2 and 4.6 mg/kg, p.o., respectively) as well as ear oedema induced by 12-O-tetradecanoylphorbol acetate (TPA; ED50 ...
Marı́a Luisa Ferrándiz +5 more
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Avarol and isoavarol from a Pacific Ocean sponge Dysidea sp.
Two hydroquinone-group-containing terpenoids have been isolated from a Pacific Ocean spongeDysidia, sp. One of them has been identified by physicochemical methods as the previously known avarol. The second, isoavarol, obtained for the first time, differs from avarol by the 4(11)-position of the double bond.
Larisa K. Shubina +4 more
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This work extends in vitro screening of antimicrobial activity of the sesquiterpene hydroquinone avarol, a main secondary metabolite of the Mediterranean sponge species Dysidea avara. The antimicrobial activity was in part evaluated by microdilution method against selected bacterial and fungal strains. Additionally, the screening included evaluation of
Boris Pejin +8 more
+7 more sources
Avarol, a cytostatically active compound from the marine sponge Dysidea avara
A main metabolic product of the sponge Dysidea avara was isolated and purified and subsequently identified as avarol by applying a series of analytical techniques, e.g. [13C]NMR, [1H]NMR and i.r. spectroscopy. This sesquiterpenoid hydroquinone was found to possess strong cytostatic activity.
Wernér E.G. Müller
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Abstract We have studied antimicrobial activity of watery extracts from the marine sponge Dysidea avara . Avarol, the main sesquiterpenoid hydroquinone of this sponge, is not its only antimicrobial agent against bacteria and fungi.
Lucio Cariello +3 more
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