Results 11 to 20 of about 346 (137)
European Journal of Medicinal Chemistry, 2016 Avarol is a marine sesquiterpenoid hydroquinone, previously isolated from the marine sponge Dysidea avara Schmidt (Dictyoceratida), with antiinflammatory, antitumor, antioxidant, antiplatelet, anti-HIV, and antipsoriatic effects. Recent findings indicate that some thio-avarol derivatives exhibit acetylcholinesterase (AChE) inhibitory activity.
Giuseppina Tommonaro +7 more
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Journal of Basic and Applied Research in BiomedicineThe rising threat of multidrug-resistant bacteria necessitates the discovery of novel antibacterial agents with distinct mechanisms of action. In this study, we investigated the antibacterial activity and mechanism of action of Avarol Quinone Terpenoid (
Syed Idid, Shahbudin Saad, Deny Susanti
doaj +3 more sources
Further in vitro biological activity evaluation of amino-, thio- and ester-derivatives of avarol [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2014 The acetylcholinesterase inhibitory and/or antitumour activities of amino-, thio- and ester-derivatives of avarol selected were evaluated for the first time at in vitro conditions. Avarol-3',4'-dithioglycol (1) and avarol-4'-(3)mercaptopropionic acid (3) were shown to be the best inhibitors of the enzyme tested (0.50 µg and IC50 0.05 mM and 0.50 µg and
Giuseppina Tommonaro +4 more
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Inhibition of neutral lipid synthesis by avarols from a marine sponge
Bioorganic & Medicinal Chemistry Letters, 2019 The effects of 14 sesquiterpene hydroquinones, including 8 marine sponge-derived avarols (1-8) and 6 semisynthetic derivatives (9-14), on lipid droplet accumulation and neutral lipid synthesis in Chinese hamster ovary (CHO) K1 cells were investigated. In intact CHO-K1 cell assays, avarol (1) markedly decreased the number and size of lipid droplets in ...
Taichi Ohshiro +6 more
openalex +3 more sources
In vitro avarol does affect the growth of Candida sp. [PDF]
Natural Product Research, 2015 This work extends in vitro screening of antimicrobial activity of avarol, the marine natural product firstly isolated from the Mediterranean sponge Dysidea avara. Its anticandidial activity was evaluated by microdilution method against eight Candida strains, two ATCC and six clinical ones.
Boris Pejin +4 more
openalex +8 more sources
Avarol Effectively Inhibits Bacillus cereus Growth
Asian Journal of Chemistry, 2014 Boris Pejin +3 more
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Enantioselective Total Synthesis and Structural Revision of Dysiherbol A. [PDF]
Angew Chem Int Ed Engl, 2021 In a key step of the first enantioselective total synthesis of the anti‐inflammatory marine meroterpene dysiherbol A, the tetra‐carbocyclic core skeleton is set‐up in a unique gold‐catalyzed double cyclization, and the ether bridge of the pentacyclic target structure is spontaneously formed under cyclopropane opening upon deprotection of a late ...
Baars J +4 more
europepmc +2 more sources
Enantioselektive Totalsynthese und Strukturrevision von Dysiherbol A
Angewandte Chemie, Volume 133, Issue 27, Page 15042-15047, June 25, 2021., 2021 In einer Schlüsselreaktion der ersten enantioselektiven Totalsynthese des entzündungshemmenden marinen Meroterpens Dysiherbol A wird das tetracarbocyclische Gerüst in einer einzigartigen Gold‐katalysierten Doppelcyclisierung aufgebaut. Die Etherbrücke der pentacyclischen Zielstruktur bildet sich spontan unter Cyclopropanöffnung während der Entschützung
Julian Baars +4 more
wiley +1 more source
The potential roles of sponges in integrated mariculture
Reviews in Aquaculture, Volume 13, Issue 3, Page 1159-1171, June 2021., 2021 Abstract This mini‐review evaluates the use of marine sponges in integrated culture systems, two decades after the idea was first proposed. It was predicted that the concept would provide a double benefit: sponges would grow faster under higher organic loadings, and filtration by sponges would improve water quality.
Mert Gökalp +5 more
wiley +1 more source
Marine Demospongiae: A Challenging Treasure of Bioactive Compounds
Marine Drugs, 2022 In the last decades, it has been demonstrated that marine organisms are a substantial source of bioactive compounds with possible biotechnological applications.
Roberta Esposito +4 more
doaj +1 more source