Results 21 to 30 of about 346 (137)

Chemical modification of β-lactoglobulin by quinines [PDF]

Journal of the Serbian Chemical Society, 2003
The avarone/avarol quinone/hydroquinone couple, as well as their derivatives show considerable antitumor activity. In this work, covalent modifications of β-lactoglobulin, isolated from cow milk, by avarone, its model compound 2-tert-butyl-1,4 ...
Novaković Irena, Vujčić Zoran M., Božić Tatjana T., Božić Nataša M., Milosavić Nenad B., Sladić Dušan M.   +5 more
doaj   +1 more source

Protein covalent modification of biologically active quinones [PDF]

Journal of the Serbian Chemical Society, 2004
The avarone/avarol quinone/hydroquinone couple shows considerable antitumor activity. In this work, covalent modification of β-lactoglobulin by avarone and its derivatives as well as by the synthetic steroidal quinone 2,5(10)-estradiene- 1,4,17-trione ...
Sladić Dušan M., Novaković Irena, Vujčić Zoran M., Božić Tatjana T., Božić Nataša M., Milić Dragan, Šolaja Bogdan A., Gašić Miroslav J.   +7 more
doaj   +1 more source

Comparative Analysis of Virulence Factors of Homozygous and Heterozygous Strains of Candida albicans Vaginal Isolates

International Journal of Microbiology, Volume 2020, Issue 1, 2020., 2020
Although the epidemiology of pathogenic Candida species is changing due to invasive diseases, Candida albicans has become the common cause of human infections worldwide. Candida albicans is a diploid yeast with a mostly clonal mode of reproduction and without known complete sexual cycle.
Hasti Nouraei, Sahar Sheykhi, Zahra ZareShahrabadi, Hossein Khodadadi, Kamiar Zomorodian, Keyvan Pakshir, Giuseppe Comi   +6 more
wiley   +1 more source

MODEL PRODUKSI SENYAWA BIOAKTIF MELALUI KULTUR SEL PADA SPONS Dysidea avara

Squalen, 2009
Spons merupakan hewan multiseluler yang paling sederhana sekaligus merupakan sumber senyawa bioaktif yang sangat berguna di dalam bidang farmasi. Senyawa-senyawa baru yang sangat beragam sudah banyak yang diisolasi dari spons.
Muhammad Nursid, Ekowati Chasanah
doaj   +1 more source

Identification of Cannabidiolic and Cannabigerolic Acids as MTDL AChE, BuChE, and BACE-1 Inhibitors Against Alzheimer's Disease by In Silico, In Vitro, and In Vivo Studies. [PDF]

Phytother Res
ABSTRACT Cannabidiolic (CBDA) and cannabigerolic (CBGA) acids are naturally occurring compounds from Cannabis sativa plant, previously identified by us as dual PPARα/γ agonists. Since the development of multitarget‐directed ligands (MTDL) represents a valuable strategy to alleviate and slow down the progression of multifactorial diseases, we evaluated ...
Vitale RM, Morace AM, D'Errico A, Ricciardi F, Fusco A, Boccella S, Guida F, Nasso R, Rading S, Karsak M, Caprioglio D, Iannotti FA, Arcone R, Luongo L, Masullo M, Maione S, Amodeo P.   +16 more
europepmc   +2 more sources

Cytotoxic Terpene Quinones from Marine Sponges

Marine Drugs, 2010
The 1,4-benzoquinone moiety is a common structural feature in a large number of compounds that have received considerable attention owing to their broad spectrum of biological activities.
Marina Gordaliza
doaj   +1 more source

In vitro evaluation of cytotoxic and mutagenic activity of avarol [PDF]

Natural Product Research, 2015
The cytotoxicity of avarol, a main secondary metabolite of the Mediterranean sponge Dysidea avara, was in vitro screened by MTT assay against four human tumour cell lines. The colon HT-29 tumour cells practically showed to be the only sensitive ones towards this organic compound.
Pejin B, Iodice C, Kojic V, Jakimov D, Lazovic M, Tommonaro G   +5 more
openaire   +3 more sources

Environmentally Friendly Antifouling Metabolites from Red Sea Organisms

Journal of Chemistry, Volume 2019, Issue 1, 2019., 2019
Seventy‐one marine organisms representing different classes of marine fauna and flora were collected from the Red Sea. They include sponges, hydrozoan, soft corals, sea cucumber, ascidian, cyanobacteria, and macroalgae. The methanolic extracts were evaluated for their toxicity and settlement inhibition effects by using cultured Balanus amphitrite ...
Sultan Semran Al-Lihaibi, Ahmed Abdel-Lateff, Walied Mohamed Alarif, Hajer Saeed Alorfi, Yasuyuki Nogata, Tatsufumi Okino, Mariana A. Reis   +6 more
wiley   +1 more source

Marine Invertebrate Natural Products for Anti‐Inflammatory and Chronic Diseases

Evidence-Based Complementary and Alternative Medicine, Volume 2013, Issue 1, 2013., 2013
The marine environment represents a relatively available source of functional ingredients that can be applied to various aspects of food processing, storage, and fortification. Moreover, numerous marine invertebrates based compounds have biological activities and also interfere with the pathogenesis of diseases.
Kalimuthu Senthilkumar, Se-Kwon Kim, Edwin L. Cooper   +2 more
wiley   +1 more source

Traditional and Modern Biomedical Prospecting: Part I—the History

Evidence-Based Complementary and Alternative Medicine, Volume 1, Issue 1, Page 71-82, 2004., 2004
Nature, especially the marine environment, provides the most effective drugs used in human therapy. Among the metazoans, the marine sponges (phylum Porifera), which are sessile filter feeders, produce the most potent and highly selective bioactive secondary metabolites.
Werner E. G. Müller, Renato Batel, Heinz C. Schröder, Isabel M. Müller   +3 more
wiley   +1 more source