Results 111 to 120 of about 415 (136)

ChemInform Abstract: Enantioselective Total Synthesis of Avarol and Avarone.

ChemInform, 2000
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Taotao Ling, Alan X. Xiang, Emmanuel A. Theodorakis   +2 more
openaire   +1 more source

New Avarone and Avarol Derivatives from the Marine Sponge Dysidea cinerea

Journal of Natural Products, 1991
Six new avarol and avarone derivatives, 3'-hydroxyavarone [3], 3',6'-dihydroxyavarone [4], 6'-hydroxyavarol [5], 6'-acetoxyavarol [6], 6'-acetoxyavarone [7], and 6'-hydroxy-4'-methoxyavarone [8], are reported from the Red Sea sponge Dysidea cinerea.
S, Hirsch, A, Rudi, Y, Kashman, Y, Loya
openaire   +2 more sources

Enantiospecific total synthesis of (+)- and (–)-avarone and -avarol

Chem. Commun., 1996
Enantiopure avarol and its oxidized congener avarone are synthesized in both podal series from an optically pure Wieland–Miescher enone; preliminary results from biochemical studies are summarized.
Edward P. Locke, Sidney M. Hecht
openaire   +1 more source

Avarol and avarone, two new anti-inflammatory agents of marine origin

European Journal of Pharmacology, 1994
The anti-inflammatory activity of avarol and avarone, sesquiterpenoid derivatives from the Mediterranean sponge Dysidea avara, was investigated. Both compounds potently inhibited paw oedema induced by carrageenan (approximated ED50 = 9.2 and 4.6 mg/kg, p.o., respectively) as well as ear oedema induced by 12-O-tetradecanoylphorbol acetate (TPA; ED50 ...
M L, Ferrándiz, M J, Sanz, G, Bustos, M, Payá, M J, Alcaraz, S, De Rosa   +5 more
openaire   +2 more sources

Synthesis and biological activity of derivatives of the marine quinone avarone

European Journal of Medicinal Chemistry, 2010
Nine alkyl(aryl)thio derivatives of the marine sesquiterpene quinone avarone were synthesized by nucleophilic addition of thiols or thiophenol to avarone. In most cases only one regioisomer was obtained. Their cytotoxic activities, brine shrimp lethality and antibacterial activity were evaluated, as well as those of some previously synthesized avarone ...
Božić, Tatjana T., Novaković, Irena, Gašić, Miroslav J., Juranić, Zorica, Stanojković, Tatjana, Tufegdžić, Srđan, Kljajić, Zoran, Sladić, Dušan   +7 more
openaire   +4 more sources

ChemInform Abstract: Stereoselective Synthesis of (+)‐Avarol, (+)‐Avarone, and Some Nonracemic Analogues.

ChemInform, 1997
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
J. AN, D. F. WIEMER
openaire   +1 more source

ChemInform Abstract: Enantiospecific Total Synthesis of (+)‐ and (‐)‐Avarone and ‐Avarol.

ChemInform, 1997
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
E. P. LOCKE, S. M. HECHT
openaire   +1 more source

Effect of avarol and avarone on in vitro-induced microsomal lipid peroxidation

Toxicology, 1992
Lipid peroxidation was employed as an experimental model to study the antioxidant properties of avarol, a sesquiterpenoid hydroquinone and of its quinone, avarone. In the NADPH- or ascorbate-linked lipid peroxidation, avarol and avarone were shown to be more effective as inhibitors than in the t-BuOOH-dependent peroxidative process.
BELISARIO, MARIA ANTONIETTA, M. Maturo, R. Pecce, G. R. D. Villani, S. De Rosa   +4 more
openaire   +5 more sources

Arylation of sulfhydryl groups in vitro by the naturally occuring sesquiterpenoid benzoquinone avarone

Toxicology, 1994
Avarone (AQ) is a naturally occurring sesquiterpenoid benzoquinone possessing antileukaemic activity. Its reactivity towards glutathione (GSH) and protein sulfhydryl (SH) groups was investigated. The stoichiometry of AQ reaction with GSH at [GSH]/[AQ] ratios lower than unity proved to be 1:2 (thiol:quinone), consistent with the formation of the ...
M A, Belisario, R, Pecce, M, Maturo, S, De Rosa   +3 more
openaire   +2 more sources

Highly Efficient Total Synthesis of the Marine Natural Products (+)‐Avarone, (+)‐Avarol, (−)‐Neoavarone, (−)‐Neoavarol and (+)‐Aureol

Chemistry – A European Journal, 2008
AbstractBiologically important and structurally unique marine natural products avarone (1), avarol (2), neoavarone (3), neoavarol (4) and aureol (5), were efficiently synthesized in a unified manner starting from (+)‐5‐methyl‐Wieland–Miescher ketone 10.
Junji, Sakurai, Takamasa, Oguchi, Kazuhiro, Watanabe, Hideki, Abe, Syu-ichi, Kanno, Masaaki, Ishikawa, Tadashi, Katoh   +6 more
openaire   +2 more sources