Results 121 to 130 of about 442 (142)

Arylation of sulfhydryl groups in vitro by the naturally occuring sesquiterpenoid benzoquinone avarone

Toxicology, 1994
Avarone (AQ) is a naturally occurring sesquiterpenoid benzoquinone possessing antileukaemic activity. Its reactivity towards glutathione (GSH) and protein sulfhydryl (SH) groups was investigated. The stoichiometry of AQ reaction with GSH at [GSH]/[AQ] ratios lower than unity proved to be 1:2 (thiol:quinone), consistent with the formation of the ...
M A, Belisario, R, Pecce, M, Maturo, S, De Rosa   +3 more
exaly   +3 more sources

ChemInform Abstract: Enantiospecific Total Synthesis of (+)‐ and (‐)‐Avarone and ‐Avarol.

ChemInform, 1997
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
E. P. LOCKE, S. M. HECHT
openaire   +1 more source

The inhibition of human immunodeficiency virus type 1 reverse transcriptase by avarol and avarone derivatives [PDF]

FEBS Letters, 1990
We have analyzed the effects of several natural compounds related to avarols and avarones on the catalytic functions of human immunodeficiency virus type 1 (HIV‐1) reverse transcriptase (RT). The most potent substances, designated as avarone A,B and E and avarol F, inhibited indiscriminately the enzymatic activities of HIV‐1 RT, namely the RNA ...
Loya, Shoshana, Hizi, Amnon
exaly   +3 more sources

Highly Efficient Total Synthesis of the Marine Natural Products (+)‐Avarone, (+)‐Avarol, (−)‐Neoavarone, (−)‐Neoavarol and (+)‐Aureol

Chemistry - A European Journal, 2008
AbstractBiologically important and structurally unique marine natural products avarone (1), avarol (2), neoavarone (3), neoavarol (4) and aureol (5), were efficiently synthesized in a unified manner starting from (+)‐5‐methyl‐Wieland–Miescher ketone 10.
Kazuhiro Watanabe, Tadashi Katoh
exaly   +3 more sources

In vitro Effect of Avarone and Avarol, a Quinone/Hydroquinone Couple of Marine Origin, on Platelet Aggregation

Pharmacology & Toxicology, 1996
Abstract: We investigated the effect on human platelet aggregation of the naturally occurring quinone/hydroquinone couple, avarone and avarol. Avarone exerted antiplatelet activity both on platelet‐rich plasma and, to a greater extent, on washed platelets. The quinone inhibited the platelet aggregatory process with all the agonists used.
M A, Belisario, M, Maturo, G, Avagnale, S, De Rosa, F, Scopacasa, M, De Caterina   +5 more
openaire   +2 more sources

Biphasic and differential effects of the cytostatic agents avarone and avarol on DNA metabolism of human and murine T and B lymphocytes

European Journal of Cancer and Clinical Oncology, 1986
The two novel antimitotic and potent antileukemic agents avarone and avarol were determined to inhibit the [3H]-dThd incorporation rates of both murine spleen and human peripheral blood lymphocytes within the concentration range of 2-6 microM. The mitogens concanavalin A (ConA; for T lymphocytes), lipopolysaccharide (LPS; for murine B lymphocytes) and ...
W E, Müller, C, Sobel, W, Sachsse, B, Diehl-Seifert, R K, Zahn, E, Eich, Z, Kljajić, H C, Schröder   +7 more
openaire   +2 more sources

ChemInform Abstract: Highly Efficient Total Synthesis of the Marine Natural Products (+)‐Avarone (Ia), (+)‐Avarol (Ib), (‐)‐Neoavarone (IIa), (‐)‐Neoavarol (IIb) and (+)‐Aureol (III).

ChemInform, 2008
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Junji Sakurai, Takamasa Oguchi, Kazuhiro Watanabe, Hideki Abe, Syu‐ichi Kanno, Masaaki Ishikawa, Tadashi Katoh   +6 more
openaire   +1 more source

Enantioselektive Totalsynthese von Avarol und Avaron

Angewandte Chemie, 1999
Taotao Ling, Alan X. Xiang, Emmanuel A. Theodorakis   +2 more
openaire   +2 more sources

Avarone and Avarol

Drugs of the Future, 1985
W.E.G. Mueller, R.K. Zahn, A. Maidhof, E. Eich, M.J. Gasic, H.C. Schroeder   +5 more
openaire   +1 more source

Potent antileukemic activity of the novel cytostatic agent avarone and its analogues in vitro and in vivo.

Cancer research, 1985
Avarone and avarol are novel cytostatic agents which have potent antileukemic activity both in vitro and in vivo (mice). Cell culture experiments revealed that the cytostatic activity of these two compounds on L5178Y mouse lymphoma cells was 13- to 14-fold higher than that determined for HeLa cells and 40- to 43-fold higher than that for human melanoma
W E, Müller, A, Maidhof, R K, Zahn, H C, Schröder, M J, Gasić, D, Heidemann, A, Bernd, B, Kurelec, E, Eich, G, Seibert   +9 more
openaire   +1 more source