Results 111 to 120 of about 442 (142)

Stereoselective Synthesis of (+)-Avarol, (+)-Avarone, and Some Nonracemic Analogues

The Journal of Organic Chemistry, 1996
Synthesis of the rearranged drimane sesquiterpenoids (+)-avarol and (+)-avarone from Wieland-Miescher ketone is described. This synthetic sequence provides convenient access to the natural enantiomers and, based on comparison of the optical rotation of synthetic avarol dimethyl ether with literature data, affords material of significantly higher ...
Jianguo, An, David F., Wiemer
openaire   +2 more sources

Synthesis and Evaluation of Cytostatic and Antiviral Activities of 3′ and 4′-Avarone Derivatives

Antiviral Chemistry and Chemotherapy, 1991
A series of 3′ and 4′-substituted avarone derivatives were synthesized and tested in culture systems as antitumour and antiviral agents in comparison to avarol and avarone. 3′-alkylamino derivatives showed potent cytostatic activities against murine L1210 and human B (Raji) and T (C8166, H9) lymphoblast cells (ID50 range 1.7–3.7 μm).
A De Giulio, S De Rosa, G Strazzullo, L Diliberto, P Obino, M E Marongiu, A Pani, P La Colla   +7 more
exaly   +6 more sources

Studies on the interactions of bioactive quinone avarone and its methylamino derivatives with calf thymus DNA

International Journal of Biological Macromolecules, 2013
The interactions of avarone, a quinone from the marine sponge Dysideaavara, and the methylamino derivatives of avarone (2), 3'-(methylamino)avarone (3) and 4'-(methylamino)avarone (4) with calf thymus DNA (CT-DNA) were studied. Agarose gel electrophoreticanalysis showed that binding of the quinones quenched fluorescence of ethidium bromide (EB).
Miroslava T Vujčić, Srđan Tufegdžić, Irena T Novakovic   +2 more
exaly   +5 more sources

Antibacterial and Antifungal Activity of Avarone and Avarol

Zentralblatt Fur Bakteriologie, Mikrobiologie, Und Hygiene Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology, 1985
The sesquiterpenoid hydroquinone and quinone, Avarol and Avarone, were previously found to be potent antitumor agents (Müller et al., 1984). In the present study it is reported that in aqueous solution (pH 7.2), in the presence of dimethylsulfoxide, Avarol is converted to Avarone.
G, Seibert, W, Raether, N, Dogović, M J, Gasić, R K, Zahn, W E, Müller   +5 more
exaly   +3 more sources

ChemInform Abstract: Enantioselective Total Synthesis of Avarol and Avarone.

ChemInform, 2000
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Taotao Ling, Alan X. Xiang, Emmanuel A. Theodorakis   +2 more
openaire   +1 more source

New Avarone and Avarol Derivatives from the Marine Sponge Dysidea cinerea

Journal of Natural Products, 1991
Six new avarol and avarone derivatives, 3'-hydroxyavarone [3], 3',6'-dihydroxyavarone [4], 6'-hydroxyavarol [5], 6'-acetoxyavarol [6], 6'-acetoxyavarone [7], and 6'-hydroxy-4'-methoxyavarone [8], are reported from the Red Sea sponge Dysidea cinerea.
S, Hirsch, A, Rudi, Y, Kashman, Y, Loya
openaire   +2 more sources

Enantiospecific total synthesis of (+)- and (–)-avarone and -avarol

Chemical Communications, 1996
Enantiopure avarol and its oxidized congener avarone are synthesized in both podal series from an optically pure Wieland–Miescher enone; preliminary results from biochemical studies are summarized.
Edward P. Locke, Sidney M. Hecht
exaly   +2 more sources

Antimutagenic activity of the novel antileukemic agents, avarone and avarol

Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 1985
The two antileukemic agents, avarone and avarol, were determined to be neither direct nor indirect mutagenic agents in the Ames microsomal test. Moreover, the two sesquiterpenoid compounds drastically reduced the mutagenic effect of benzo[a]pyrene in the same system.
B, Kurelec, R K, Zahn, M J, Gasić, S, Britvić, D, Lucić, W E, Müller   +5 more
exaly   +3 more sources

Effect of avarol, avarone and nine of their natural and synthetic derivatives on microsomal drug-metabolizing enzymes

Toxicology Letters, 1991
Avarol, a sesquiterpenoid hydroquinone, its quinone avarone, both main secondary metabolites from the marine sponge Dysidea avara and nine of their natural and synthetic derivatives were tested for ability to interact selectively with rat liver microsomal phenobarbital (PB)- or 3-methylcholanthrene (3-MC)-induced cytochrome (cyt.) P-450 isoenzymatic ...
Alfonso De Giulio
exaly   +3 more sources

ChemInform Abstract: Stereoselective Synthesis of (+)‐Avarol, (+)‐Avarone, and Some Nonracemic Analogues.

ChemInform, 1997
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
J. AN, D. F. WIEMER
openaire   +1 more source