Results 91 to 100 of about 203 (113)

New Avarone and Avarol Derivatives from the Marine Sponge Dysidea cinerea

Journal of Natural Products, 1991
Six new avarol and avarone derivatives, 3'-hydroxyavarone [3], 3',6'-dihydroxyavarone [4], 6'-hydroxyavarol [5], 6'-acetoxyavarol [6], 6'-acetoxyavarone [7], and 6'-hydroxy-4'-methoxyavarone [8], are reported from the Red Sea sponge Dysidea cinerea.
S, Hirsch, A, Rudi, Y, Kashman, Y, Loya
openaire   +2 more sources

ChemInform Abstract: Stereoselective Synthesis of (+)‐Avarol, (+)‐Avarone, and Some Nonracemic Analogues.

ChemInform, 1997
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
J. AN, D. F. WIEMER
openaire   +1 more source

Highly Efficient Total Synthesis of the Marine Natural Products (+)-Avarone, (+)-Avarol, (−)-Neoavarone, (−)-Neoavarol and (+)-Aureol

Chemistry - A European Journal, 2008
AbstractBiologically important and structurally unique marine natural products avarone (1), avarol (2), neoavarone (3), neoavarol (4) and aureol (5), were efficiently synthesized in a unified manner starting from (+)‐5‐methyl‐Wieland–Miescher ketone 10.
Tadashi Katoh, Kazuhiro Watanabe, Takamasa Oguchi   +2 more
exaly   +3 more sources

In vitro Effect of Avarone and Avarol, a Quinone/Hydroquinone Couple of Marine Origin, on Platelet Aggregation

Pharmacology & Toxicology, 1996
Abstract: We investigated the effect on human platelet aggregation of the naturally occurring quinone/hydroquinone couple, avarone and avarol. Avarone exerted antiplatelet activity both on platelet‐rich plasma and, to a greater extent, on washed platelets. The quinone inhibited the platelet aggregatory process with all the agonists used.
M A, Belisario, M, Maturo, G, Avagnale, S, De Rosa, F, Scopacasa, M, De Caterina   +5 more
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Biphasic and differential effects of the cytostatic agents avarone and avarol on DNA metabolism of human and murine T and B lymphocytes

European Journal of Cancer and Clinical Oncology, 1986
The two novel antimitotic and potent antileukemic agents avarone and avarol were determined to inhibit the [3H]-dThd incorporation rates of both murine spleen and human peripheral blood lymphocytes within the concentration range of 2-6 microM. The mitogens concanavalin A (ConA; for T lymphocytes), lipopolysaccharide (LPS; for murine B lymphocytes) and ...
W E, Müller, C, Sobel, W, Sachsse, B, Diehl-Seifert, R K, Zahn, E, Eich, Z, Kljajić, H C, Schröder   +7 more
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Enantioselektive Totalsynthese von Avarol und Avaron

Angewandte Chemie, 1999
Taotao Ling, Alan X. Xiang, Emmanuel A. Theodorakis   +2 more
openaire   +2 more sources

Avarone and Avarol

Drugs of the Future, 1985
W.E.G. Mueller, R.K. Zahn, A. Maidhof, E. Eich, M.J. Gasic, H.C. Schroeder   +5 more
openaire   +1 more source

A study of the interactions of cytotoxic amino acid derivatives of avarone with biomacromolecules

2017
A series of derivatives of marine sesquiterpene quinone avarone with amino acids with non-polar aliphatic and aromatic residues has been synthesized and their cytotoxic activity against a panel of tumor cell lines has been investigated. (a) In order to understand the mechanism of action of the mentioned quinone anticancer agens, the study of the ...
Vilipić, Jovana, Novaković, Irena, Zlatović, Mario, Vujčić, Miroslava, Anđelković, Ljubica, Sladić, Dušan   +5 more
openaire   +1 more source

Potent antileukemic activity of the novel cytostatic agent avarone and its analogues in vitro and in vivo.

Cancer research, 1985
Avarone and avarol are novel cytostatic agents which have potent antileukemic activity both in vitro and in vivo (mice). Cell culture experiments revealed that the cytostatic activity of these two compounds on L5178Y mouse lymphoma cells was 13- to 14-fold higher than that determined for HeLa cells and 40- to 43-fold higher than that for human melanoma
W E, Müller, A, Maidhof, R K, Zahn, H C, Schröder, M J, Gasić, D, Heidemann, A, Bernd, B, Kurelec, E, Eich, G, Seibert   +9 more
openaire   +1 more source

Evidence of Insulin-Sensitizing and Mimetic Activity of the Sesquiterpene Quinone Avarone, a Protein Tyrosine Phosphatase 1B and Aldose Reductase Dual Targeting Agent From the Marine Sponge Dysidea avara

Pharmaceutics, 2023
Marcello Casertano, Paolo Paoli, Concetta Imperatore   +2 more
exaly