Results 91 to 100 of about 272 (123)

Stereoselective Synthesis of (+)-Avarol, (+)-Avarone, and Some Nonracemic Analogues.

The Journal of Organic Chemistry, 1996
Synthesis of the rearranged drimane sesquiterpenoids (+)-avarol and (+)-avarone from Wieland-Miescher ketone is described. This synthetic sequence provides convenient access to the natural enantiomers and, based on comparison of the optical rotation of synthetic avarol dimethyl ether with literature data, affords material of significantly higher ...
Jianguo An, D. Wiemer
semanticscholar   +3 more sources

Further in vitro evaluation of cytotoxicity of the marine natural product derivative 4′-leucine-avarone

Natural Product Research, 2014
The cytotoxicity of 4′-leucine-avarone, amino derivative of the sponge Dysidea avara secondary metabolite avarone, was evaluated by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide assay in vitro against seven human solid tumours for the first time.
B. Pejin, C. Iodice, G. Tommonaro, G. Bogdanovic, V. Kojić, S. De Rosa   +5 more
semanticscholar   +5 more sources

In vitro Effect of Avarone and Avarol, a Quinone/Hydroquinone Couple of Marine Origin, on Platelet Aggregation

Basic and Clinical Pharmacology and Toxicology, 1996
S De Rosa
exaly   +2 more sources

Arylation of sulfhydryl groups in vitro by the naturally occuring sesquiterpenoid benzoquinone avarone

Toxicology, 1994
Avarone (AQ) is a naturally occurring sesquiterpenoid benzoquinone possessing antileukaemic activity. Its reactivity towards glutathione (GSH) and protein sulfhydryl (SH) groups was investigated. The stoichiometry of AQ reaction with GSH at [GSH]/[AQ] ratios lower than unity proved to be 1:2 (thiol:quinone), consistent with the formation of the ...
S De Rosa
exaly   +3 more sources

Highly efficient total synthesis of the marine natural products (+)-avarone, (+)-avarol, (-)-neoavarone, (-)-neoavarol and (+)-aureol.

Chemistry – A European Journal, 2008
AbstractBiologically important and structurally unique marine natural products avarone (1), avarol (2), neoavarone (3), neoavarol (4) and aureol (5), were efficiently synthesized in a unified manner starting from (+)‐5‐methyl‐Wieland–Miescher ketone 10.
Junji Sakurai, Takamasa Oguchi, Kazuhiro Watanabe, H. Abe, Syu-ichi Kanno, M. Ishikawa, T. Katoh   +6 more
semanticscholar   +3 more sources

Enantiospecific Total Synthesis of (+)- and (-)-Avarone and -Avarol.

ChemInform, 2010
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
E. Locke, S. Hecht
semanticscholar   +2 more sources

Stereoselective Synthesis of (+)‐Avarol, (+)‐Avarone, and Some Nonracemic Analogues.

ChemInform, 1997
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Jianguo An, D. Wiemer
semanticscholar   +2 more sources

ChemInform Abstract: Enantioselective Total Synthesis of Avarol and Avarone.

ChemInform, 2000
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Taotao Ling, Alan X. Xiang, Emmanuel A. Theodorakis   +2 more
openaire   +1 more source

Mechanism of oxidation of 1-benzyl-1,4-dihydronicotinamide by the biologically active p-benzoquinone derivative, avarone, in a cationic micellar medium

Bioelectrochemistry and Bioenergetics, 1991
A. Davidović, I. Tabaković, D. Sladic, N. Dogović, M. Gašić   +4 more
semanticscholar   +2 more sources

In vitro Effect of Avarone and Avarol, a Quinone/Hydroquinone Couple of Marine Origin, on Platelet Aggregation

Pharmacology & Toxicology, 1996
Abstract: We investigated the effect on human platelet aggregation of the naturally occurring quinone/hydroquinone couple, avarone and avarol. Avarone exerted antiplatelet activity both on platelet‐rich plasma and, to a greater extent, on washed platelets. The quinone inhibited the platelet aggregatory process with all the agonists used.
M A, Belisario, M, Maturo, G, Avagnale, S, De Rosa, F, Scopacasa, M, De Caterina   +5 more
openaire   +2 more sources