Results 81 to 90 of about 272 (123)

Effect of avarol and avarone on in vitro-induced microsomal lipid peroxidation

Toxicology, 1992
Lipid peroxidation was employed as an experimental model to study the antioxidant properties of avarol, a sesquiterpenoid hydroquinone and of its quinone, avarone. In the NADPH- or ascorbate-linked lipid peroxidation, avarol and avarone were shown to be more effective as inhibitors than in the t-BuOOH-dependent peroxidative process.
Guglielmo Rosario Domenico Villani, S De Rosa   +1 more
exaly   +7 more sources

Avarol and avarone, two new anti-inflammatory agents of marine origin

European Journal of Pharmacology, 1994
The anti-inflammatory activity of avarol and avarone, sesquiterpenoid derivatives from the Mediterranean sponge Dysidea avara, was investigated. Both compounds potently inhibited paw oedema induced by carrageenan (approximated ED50 = 9.2 and 4.6 mg/kg, p.o., respectively) as well as ear oedema induced by 12-O-tetradecanoylphorbol acetate (TPA; ED50 ...
Maria JOSÉ Alcaraz, Maria Jesus Sanz, Mª Luisa Ferrándiz   +2 more
exaly   +4 more sources

Antibacterial and Antifungal Activity of Avarone and Avarol

Zentralblatt Fur Bakteriologie, Mikrobiologie, Und Hygiene Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology, 1985
The sesquiterpenoid hydroquinone and quinone, Avarol and Avarone, were previously found to be potent antitumor agents (Müller et al., 1984). In the present study it is reported that in aqueous solution (pH 7.2), in the presence of dimethylsulfoxide, Avarol is converted to Avarone.
Werner E G Müller, Gerhard Seibert, R K Zahn   +2 more
exaly   +4 more sources

Enantioselective Total Synthesis of Avarol and Avarone

Angewandte Chemie - International Edition, 1999
Formation of the C11-C1' bond through application of Barton's radical decarboxylation and quinone addition is the cornerstone of a new convergent and concise synthesis of the marine metabolites avarol (1) and avarone (2; see scheme), for which antimitotic, antileukemic, and antiviral effects have been reported.
Emmanuel Theodorakis
exaly   +4 more sources

Studies on the interactions of bioactive quinone avarone and its methylamino derivatives with calf thymus DNA

International Journal of Biological Macromolecules, 2013
The interactions of avarone, a quinone from the marine sponge Dysideaavara, and the methylamino derivatives of avarone (2), 3'-(methylamino)avarone (3) and 4'-(methylamino)avarone (4) with calf thymus DNA (CT-DNA) were studied. Agarose gel electrophoreticanalysis showed that binding of the quinones quenched fluorescence of ethidium bromide (EB).
MIROSLAVA Vujčić, Irena Novakovic, Daniela Djikanovic   +2 more
exaly   +6 more sources

Antimutagenic activity of the novel antileukemic agents, avarone and avarol

Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 1985
The two antileukemic agents, avarone and avarol, were determined to be neither direct nor indirect mutagenic agents in the Ames microsomal test. Moreover, the two sesquiterpenoid compounds drastically reduced the mutagenic effect of benzo[a]pyrene in the same system.
Werner E G Müller, S Britvić, B Kurelec   +2 more
exaly   +4 more sources

New Avarone and Avarol Derivatives from the Marine Sponge Dysidea cinerea

Journal of Natural Products, 1991
Six new avarol and avarone derivatives, 3'-hydroxyavarone [3], 3',6'-dihydroxyavarone [4], 6'-hydroxyavarol [5], 6'-acetoxyavarol [6], 6'-acetoxyavarone [7], and 6'-hydroxy-4'-methoxyavarone [8], are reported from the Red Sea sponge Dysidea cinerea.
Yossi Loya, Y Kashman
exaly   +4 more sources

Enantiospecific total synthesis of (+)- and (–)-avarone and -avarol

Chemical Communications, 1996
Enantiopure avarol and its oxidized congener avarone are synthesized in both podal series from an optically pure Wieland–Miescher enone; preliminary results from biochemical studies are summarized.
Sidney Hecht
exaly   +3 more sources

Effect of avarol, avarone and nine of their natural and synthetic derivatives on microsomal drug-metabolizing enzymes

Toxicology Letters, 1991
Avarol, a sesquiterpenoid hydroquinone, its quinone avarone, both main secondary metabolites from the marine sponge Dysidea avara and nine of their natural and synthetic derivatives were tested for ability to interact selectively with rat liver microsomal phenobarbital (PB)- or 3-methylcholanthrene (3-MC)-induced cytochrome (cyt.) P-450 isoenzymatic ...
Alfonso De Giulio, S De Rosa
exaly   +4 more sources

Biphasic and differential effects of the cytostatic agents avarone and avarol on DNA metabolism of human and murine T and B lymphocytes

European Journal of Cancer & Clinical Oncology, 1986
The two novel antimitotic and potent antileukemic agents avarone and avarol were determined to inhibit the [3H]-dThd incorporation rates of both murine spleen and human peripheral blood lymphocytes within the concentration range of 2-6 microM. The mitogens concanavalin A (ConA; for T lymphocytes), lipopolysaccharide (LPS; for murine B lymphocytes) and ...
Werner E G Müller, R K Zahn, R K Zahn
exaly   +4 more sources