Further insight into the bioactivity of the freshwater sponge Ochridaspongia rotunda. [PDF]
Pharm Biol, 2017 Talevska A +3 more
europepmc +1 more source
Investigation of interactions of biologically active quinone avarone and its derivates with lysozyme, linear and circular deoxyribonucleic acid [PDF]
, 2013 openaire +1 more source
A focused library synthesis and cytotoxicity of quinones derived from the natural product bolinaquinone. [PDF]
R Soc Open Sci, 2018 Ghods A +5 more
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Synthesis and biological activity of derivatives of the marine quinone avarone
European Journal of Medicinal Chemistry, 2010Nine alkyl(aryl)thio derivatives of the marine sesquiterpene quinone avarone were synthesized by nucleophilic addition of thiols or thiophenol to avarone. In most cases only one regioisomer was obtained. Their cytotoxic activities, brine shrimp lethality and antibacterial activity were evaluated, as well as those of some previously synthesized avarone ...
Tatjana Bozic +2 more
exaly +5 more sources
Synthesis and Evaluation of Cytostatic and Antiviral Activities of 3′ and 4′-Avarone Derivatives
Antiviral Chemistry and Chemotherapy, 1991 A series of 3′ and 4′-substituted avarone derivatives were synthesized and tested in culture systems as antitumour and antiviral agents in comparison to avarol and avarone. 3′-alkylamino derivatives showed potent cytostatic activities against murine L1210 and human B (Raji) and T (C8166, H9) lymphoblast cells (ID50 range 1.7–3.7 μm).
Salvatore De Rosa +2 more
exaly +6 more sources
Effect of avarol and avarone on in vitro-induced microsomal lipid peroxidation
Toxicology, 1992Lipid peroxidation was employed as an experimental model to study the antioxidant properties of avarol, a sesquiterpenoid hydroquinone and of its quinone, avarone. In the NADPH- or ascorbate-linked lipid peroxidation, avarol and avarone were shown to be more effective as inhibitors than in the t-BuOOH-dependent peroxidative process.
Salvatore De Rosa +1 more
exaly +6 more sources
Antibacterial and Antifungal Activity of Avarone and Avarol
Zentralblatt Fur Bakteriologie, Mikrobiologie, Und Hygiene Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology, 1985The sesquiterpenoid hydroquinone and quinone, Avarol and Avarone, were previously found to be potent antitumor agents (Müller et al., 1984). In the present study it is reported that in aqueous solution (pH 7.2), in the presence of dimethylsulfoxide, Avarol is converted to Avarone.
Gerhard Seibert +2 more
exaly +3 more sources
Enantiospecific total synthesis of (+)- and (–)-avarone and -avarol
Chemical Communications, 1996Enantiopure avarol and its oxidized congener avarone are synthesized in both podal series from an optically pure Wieland–Miescher enone; preliminary results from biochemical studies are summarized.
Sidney M Hecht
exaly +2 more sources
Avarol and avarone, two new anti-inflammatory agents of marine origin
European Journal of Pharmacology, 1994The anti-inflammatory activity of avarol and avarone, sesquiterpenoid derivatives from the Mediterranean sponge Dysidea avara, was investigated. Both compounds potently inhibited paw oedema induced by carrageenan (approximated ED50 = 9.2 and 4.6 mg/kg, p.o., respectively) as well as ear oedema induced by 12-O-tetradecanoylphorbol acetate (TPA; ED50 ...
Maria Luisa Ferrándiz +2 more
exaly +3 more sources