Results 91 to 100 of about 15,349,054 (298)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Forecasting with Deep Learning: Beyond Average of Average of Average Performance

Accurate evaluation of forecasting models is essential for ensuring reliable predictions. Current practices for evaluating and comparing forecasting models focus on summarising performance into a single score, using metrics such as SMAPE. We hypothesize that averaging performance over all samples dilutes relevant information about the relative ...
Vitor Cerqueira, Luis Roque, Carlos Soares   +2 more
openaire   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Average-Case Complexity of Shellsort

, 1999
We prove a general lower bound on the average-case complexity of Shellsort: the average number of data-movements (and comparisons) made by a $p$-pass Shellsort for any incremental sequence is $\Omega (pn^{1 + 1/p)$ for all $p \leq \log n$.
Jiang, Tao, Li, Ming, Vitanyi, Paul
core   +1 more source

Secure and Privacy-Preserving Average Consensus

, 2017
Average consensus is fundamental for distributed systems since it underpins key functionalities of such systems ranging from distributed information fusion, decision-making, to decentralized control.
Ahmad, Muaz, Ruan, Minghao, Wang, Yongqiang   +2 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The Method of Signal Processing when Measuring Non-stationary Values

Energy Engineering and Control Systems, 2015
Nowadays the problem of quick-changing non-stationary values measurement is extremely actual in various modern technical systems (parameters control of engine combustion chamber, testing of aerospace complex products, scientific researches etc.).
Myroslav Tykhan, Orest Ivakhiv, Vasyl Teslyuk   +2 more
doaj   +1 more source

Average luminosity distance in inhomogeneous universes

, 2010
The paper studies the correction to the distance modulus induced by inhomogeneities and averaged over all directions from a given observer. The inhomogeneities are modeled as mass-compensated voids in random or regular lattices within Swiss-cheese ...
A. Fairall, A. Ishibashi, A. Lemaître, A. Sandage, A. Sandage ., A.G. Riess ., B. Granett, B.R. Granett, C. Foster, D.D. Kocevski, G. Ellis, H. Bondi, H.G. Rose, HST collaboration, I. Zehavi, J. Neill, J. Silk, J.A. Willick, J.R. Mould ., K. Van Acoleyen, L. da Costa ., M. Einasto ., M. Hicken ., N. Brouzakis, N. Mustapha, P.J.E. Peebles, R. Giovanelli ., R. Kessler ., S. Jha, T. Haugboelle ., V. Marra, V. Mukhanov, Valentin Kostov, W. Valkenburg, X. Shi, X.-D. Shi   +35 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Familiarity and Voice Representation: From Acoustic-Based Representation to Voice Averages

Frontiers in Psychology, 2017
The ability to recognize an individual from their voice is a widespread ability with a long evolutionary history. Yet, the perceptual representation of familiar voices is ill-defined.
Maureen Fontaine, Scott A. Love, Marianne Latinus   +2 more
doaj   +1 more source