Results 111 to 120 of about 12,298,066 (345)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Changing mortality and average cohort life expectancy [PDF]
Period life expectancy varies with changes in mortality, and should not be confused with the life expectancy of those alive during that period. Given past and likely future mortality changes, a recent debate has arisen on the usefulness of the period ...
Robert Schoen, Vladimir Canudas-Romo
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Translating the A1C Assay Into Estimated Average Glucose Values
Diabetes Care, 2008 OBJECTIVE—The A1C assay, expressed as the percent of hemoglobin that is glycated, measures chronic glycemia and is widely used to judge the adequacy of diabetes treatment and adjust therapy. Day-to-day management is guided by self-monitoring of capillary
D. Nathan +5 more
semanticscholar +1 more source
321W average power, 1GHz, 20ps 1060nm pulsed fiber MOPA source [PDF]
, 2005 Pulses from a gain-switched laser diode were amplified in a fiber MOPA system to produce in excess of 320W of average power in 20ps pulses at 1GHz repetition rate at ...
M. Ibsen +19 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Annalen der Physik, 2015 We investigate in detail a recently introduced “coherent averaging scheme” in terms of its usefulness for achieving Heisenberg limited sensitivity in the measurement of different parameters. In the scheme, N quantum probes in a product state interact with a quantum bus.
Fraïsse, Julien Mathieu Elias +1 more
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Variable Transmission Range Routing Protocol Based on Vehicle Density in VANET
Dianxin kexue, 2015 In order to solve the problem of unstable connectivity and high bit error rate,which are caused by rapid changes in the density of vehicles on the road,while the transmission radius remained unchanged,a variable transmission range routing protocols based
Rong Cai, Guoan Zhang, Yuebo Wu
doaj