Results 51 to 60 of about 957,315 (213)

Blood Pressure Responses During Exercise Were Associated With Average Home Blood Pressure and Home Blood Pressure Variability: The Electronic Framingham Heart Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Abnormal exercise blood pressure (BP) responses are associated with hypertension and cardiovascular disease, but their relationship with home BP over a mid‐ to long‐term time span is unknown. Methods At an FHS (Framingham Heart Study) research
Xuzhi Wang, Yuankai Zhang, Chathurangi H. Pathiravasan, Nicole L. Spartano, Emelia J. Benjamin, David D. McManus, Gregory D. Lewis, Martin G. Larson, Ramachandran S. Vasan, Joanne M. Murabito, Chunyu Liu, Matthew Nayor   +11 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Queuing theory & discrete simulation as a tool to improve medicine deliver center service levels [PDF]

Yugoslav Journal of Operations Research
The increasing demand for medical services and supplies as medicine delivery has been found in applied mathematical models, such as queuing theory, a tool to analyze and improve medical processes.
Hinestroza Torres Maria Alexandra, Ruiz Morcillo Camila, Anacona Mopan Yesid Ediver, Paz Orozco Helmer, Chong Mario, Luna Ana, de Brito Junior Irineu   +6 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

S22-2: The Validation of Real-World Digital Mobility Outcomes

Baltic Journal of Sport and Health Sciences
Purpose: Despite the increasing relevance of mobility impairment, there are no tools available to measure it in the real-world. The European Mobilise-D project developed 24 digital mobility outcomes (DMOs) to assess real-world mobility that target ...
Anja Frei, Michael Long, Julia Braun, Sarah Koch, Joren Buekers, Milo Puhan, Judith Garcia-Aymerich   +6 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Relationship between morning blood pressure variability and cerebral microbleed burden in patients with hypertension

The Journal of Clinical Hypertension
Cerebral microbleeds (CMBs) can be understood as a type of target organ damage caused by hypertension. We aimed to explore the association of the CMB burden with morning blood pressure (BP) variability in patients with hypertension.
Dongsen Zhang, Hongying Ma, Chunqin Liu, Yongqiu Li   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Composite Spatiotemporal Traffic Instability Metric for Early Congestion Detection in Underground Expressways

Applied Sciences
Traffic flow in long underground expressways is expected to exhibit amplified spatiotemporal variability due to confined geometry, longitudinal gradients, limited recovery space, and heterogeneous vehicle interactions.
Choongheon Yang, Chunjoo Yoon
doaj   +1 more source