Results 61 to 70 of about 957,315 (213)

Movement measurements at home for multiple sclerosis: walking speed measured by a novel ambient measurement system

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2018
Background Gait disturbance is a major contributor to clinical disability in multiple sclerosis (MS). A sensor was developed to assess walking speed at home for people with MS using infrared technology in real-time without the use of wearables. Objective
Victoria MJ Smith, Jonathan S Varsanik, Rachel A Walker, Andrew W Russo, Kevin R Patel, Wendy Gabel, Glenn A Phillips, Zebadiah M Kimmel, Eric C Klawiter   +8 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

BMI variability and cardiovascular outcomes within clinical trial and real-world environments in type 2 diabetes: an IMI2 SOPHIA study

Cardiovascular Diabetology
Background BMI variability has been associated with increased cardiovascular disease risk in individuals with type 2 diabetes, however comparison between clinical studies and real-world observational evidence has been lacking.
Robert J. Massey, Yu Chen, Marina Panova-Noeva, Michaela Mattheus, Moneeza K. Siddiqui, Nanette C. Schloot, Antonio Ceriello, Ewan R. Pearson, Adem Y. Dawed   +8 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Development of a VSS-EWMA chart for coefficient of variation with application to production process

Scientific Reports
This study introduces a novel Variable Sample Size Exponentially Weighted Moving Average (VSS-EWMA) control chart for monitoring the coefficient of variation, termed as Dynamic Adaptive CV (DACV) chart. Tailored for dynamic production settings where both
Amna Safeer, Maysaa Elmahi Abd Elwahab, Muhammad Nabi   +2 more
doaj   +1 more source

A method for the dynamic management of genetic variability in dairy cattle

Genetics Selection Evolution, 2004
According to the general approach developed in this paper, dynamic management of genetic variability in selected populations of dairy cattle is carried out for three simultaneous purposes: procreation of young bulls to be further progeny-tested, use of ...
Briend Michèle, Moureaux Sophie, Colleau Jean-Jacques, Bechu Jérôme   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Association of hemodynamic variability during endovascular stroke treatment with functional outcome and parenchymal hemorrhage

Therapeutic Advances in Neurological Disorders
Background: Higher blood pressure variability (BPV) in patients suffering from acute ischemic stroke were shown to be associated with worse functional outcome and hemorrhagic transformation.
Min Chen, Lukas D. Sauer, Arne Potreck, Meinhard Kieser, Martin Bendszus, Peter Ringleb, Markus Möhlenbruch, Silvia Schönenberger   +7 more
doaj   +1 more source

Relationship Between Short-Term Blood Pressure Variability and Incidence of Acute Kidney Injury in Critically Ill Patients

Kidney & Blood Pressure Research, 2017
Background/Aims: Blood pressure (BP) variability is associated with cardiovascular events, and cerebral and renal damage. The aim of this study was to investigate any potential relationship between short-term BP variability and incidence of acute onset ...
Zhichao Xie, Xuelian Liao, Wanhong Yin, Yan Kang, Jun Guo, Meizhu Lu   +5 more
doaj   +1 more source