Results 141 to 150 of about 10,399,569 (323)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Analyses of ACPL thermal/fluid conditioning system [PDF]
Results of engineering analyses are reported. Initial computations were made using a modified control transfer function where the systems performance was characterized parametrically using an analytical model.
Stephen, L. A., Usher, L. H.
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The Impact of Bill C-12 on New Entrants and Re-Entrants [PDF]
This report examines the impact on Employment Insurance (EI) eligibility of the increase in the entrance requirement for new entrants and re-entrants, under Bill C-12, from 20 to 26 weeks (or equivalent 910 hours).
Kapsalis, Constantine
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
پزشکی بالینی ابن سینا, 2009 Introduction & Objective: Postoperative acute pain is a complex reaction to tissue injury , visceral distention or a disease that causes harmful physiologic effects on several organs.
Hamidreza Arti, Hamidreza Azizi
doaj
Analysis of nutritional status and needs of 10th-grade high school students
Sriwijaya Journal of SportResearch Problems: In Indonesia, nutritional problems, including those in adolescent children, are increasing yearly. Research Objectives: This research aims to analyse the nutritional status and needs of class X.2 students at SMAS Karya Wisata Singaraja.
I Kadek Eka Putra Yasa +2 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source