Results 91 to 100 of about 4,712,566 (254)
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
A Class of Unbiased Estimators of the Average Treatment Effect in Randomized Experiments
Journal of Causal Inference, 2013 We derive a class of design-based estimators for the average treatment effect that are unbiased whenever the treatment assignment process is known. We generalize these estimators to include unbiased covariate adjustment using any model for outcomes that ...
Aronow Peter M., Middleton Joel A.
doaj +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Minimizing Bias in Selection on Observables Estimators When Unconfoundness Fails [PDF]
We characterize the bias of propensity score based estimators of common average treatment effect parameters in the case of selection on unobservables. We then propose a new minimum biased estimator of the average treatment effect.
Millimet, Daniel L., Tchernis, Rusty
core
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Beyond Just the Average Effect: Variation in Head Start Treatment Effects on Parenting Behavior
AERA Open, 2020 Parent engagement has been a cornerstone of Head Start since its inception in 1965. Prior studies have found evidence for small to moderate impacts of Head Start on parenting behaviors but have not considered the possibility that individual Head Start ...
Christina M. Padilla
doaj +1 more source
Beyond the average treatment effect
, 2023 The overall aim of this thesis is to explore the use of baseline risk prediction models as the basis for medical decision making. We study and apply methods for the evaluation of treatment effect heterogeneity in both clinical trial data and observational data. More specifically, we systematically review the existing literature on predictive approaches
openaire +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Estimating average partial effects under conditional moment independence assumptions [PDF]
I show how to identify and estimate the average partial effect of explanatory variables in a model where unobserved heterogeneity interacts with the explanatory variables and may be unconditionally correlated with the explanatory variables.
Jeffrey M. Wooldridge
core
Complementarity and Identification
, 2016 This paper examines the identification power of assumptions that formalize the notion of complementarity in the context of a nonparametric bounds analysis of treatment response.
Twinam, Tate
core +1 more source