Results 91 to 100 of about 505,151 (317)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Systematic errors in global air-sea CO2 flux caused by temporal averaging of sea-level pressure [PDF]
, 2005 Long-term temporal averaging of meteorological data, such as wind speed and air pressure, can cause large errors in air-sea carbon flux estimates. Other researchers have already shown that time averaging of wind speed data creates large errors in flux ...
H. Kettle +3 more
core +1 more source
Parametric Resonance in the Logistic Equation with Delay under a Two-Frequency Perturbation
Моделирование и анализ информационных систем, 2013 A logistic equation with a delay feedback circuit and with periodic perturbation of parameters is considered. The problem parameters (a coefficient of the linear growth and a delay) are chosen close to the critical values at which a cycle is bifurcated ...
N. D. Bykova +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
BAYESIAN CURVE ESTIMATION BY MODEL AVERAGING [PDF]
A bayesian approach is used to estimate a nonparametric regression model. The main features of the procedure are, first, the functional form of the curve is approximated by a mixture of local polynomials by Bayesian Model Averaging (BMA); second, the ...
M. Dolores Redondas, Daniel Peña
core
Applying the Averaging Principle to a Logistic Equation with Rapidly Oscillating Delay
Моделирование и анализ информационных систем, 2014 The problem about the local dynamics of the logistic equation with rapidly oscillating time-periodic piecewise constant coefficient of delay was considered. It was shown that the averaged equation is a logistic equation with two delays.
N. D. Bykova, E. V. Grigorieva
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Calculating Lyapunov Value for the Logistic Equation with Rapidly Oscillating Delay
Моделирование и анализ информационных систем, 2014 We consider the local dynamic of the logistic equation with rapidly oscillating timeperiodic piecewise constant or piecewise linear coefficient of delay.
N. D. Bykova
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Bayesian Model Averaging in the Context of Spatial Hedonic Pricing: An Application to Farmland Values [PDF]
Since 1973, British Columbia created an Agricultural Land Reserve to protect farmland from development. In this study, we employ GIS-based hedonic pricing models of farmland values to examine factors that affect farmland prices.
Geerte Cotteleer +2 more
core