Results 71 to 80 of about 1,540,986 (287)
EMS Surveys in Mathematical SciencesMany classical examples of models of self-organized dynamics, including the Cucker–Smale, Motsch–Tadmor, multi-species, and several others, include an alignment force that is based upon density-weighted averaging protocol. Those protocols can be viewed as special cases of “environmental averaging”.
openaire +2 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Averaging orthogonal projectors
, 2012 Dimensionality is a major concern in analyzing large data sets. Some well known dimension reduction methods are for example principal component analysis (PCA), invariant coordinate selection (ICS), sliced inverse regression (SIR), sliced average variance
Liski, Eero +3 more
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Choices and affective reactions to negative life events [PDF]
Judgment and Decision Making, 2008 Three experiments investigated individuals' preferences and affective reactions to negative life experiences. Participants had a more intense negative affective reaction when they were exposed to a highly negative life experience than when they were ...
John J. Seta +2 more
doaj
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Fuzzy Connectives for Efficient Image Reduction and Speeding Up Image Analysis
IEEE Access, 2018 We discuss non-monotone fuzzy connectives in large-scale image processing. We present an image reduction algorithm capable of differentiating between fine image details and noise in the image, particularly salt and pepper noise.
Gleb Beliakov +4 more
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Mathware & soft computing, 2001 This paper deals with the sets of strict conjectures and consequences of a given collection $P$ of premises. The set of Averaging Functions is introduced on lattices and some properties of these functions are shown. Averaging Functions allow to interpret "restricted consequences'' as averages of premises.
Trillas i Gay, Enric +2 more
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Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source