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Using labeled cDNA specific for the detection of the src gene of avian sarcoma viruses, we find that avian myelocytomatosis virus strain MC29 and avian erythroblastosis virus strain ES4 lack nucleotide sequences related to the src gene. Furthermore, chicken fibroblasts as well as hematopoietic cells, infected and transformed with these viruses, show no
D. Stéhelin, T. Graf
semanticscholar +5 more sources
Uninfected avian cells contain RNA related to the transforming gene of avian sarcoma viruses.
Cell, 1978Abstract A single gene ( src ) is responsible for neoplastic transformation induced by infection of fibroblasts with avian sarcoma viruses. We have reported previously that the DNAs of uninfected avian cells contain nucleotide sequences related to src , and that these sequences (denoted sarc ) have been highly conserved during the evolution of birds
Deborah H. Spector +7 more
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