Results 101 to 110 of about 4,311,826 (305)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Investigating climate change perceptions and behaviors from a microscopic perspective in four mountain villages in Taiwan

Frontiers in Environmental Science
Formulating climate change adaptation strategies based on local perceptions and behaviors, especially in mountainous areas, is challenging for managers.
Ying-Ta Chen, Jiunn-Cheng Lin, Su-Fen Wang, Pei-Jung Wang   +3 more
doaj   +1 more source

EMBEDDED LEARNING ROBOT WITH FUZZY Q-LEARNING FOR OBSTACLE AVOIDANCE BEHAVIOR [PDF]

, 2009
Fuzzy Q-learning is extending of Q-learning algorithm that uses fuzzy inference system to enable Q-learning holding continuous action and state. This learning has been implemented in various robot learning application like obstacle avoidance and target ...
Anam, Khairul
core  

Evidence for a Spatial Gradient of Avoidance Behavior in Humans

, 1974
The functional relationship between human avoidance behavior and spatial proximity of a fear stimulus was studied by allowing 4 adults to control the approach of a fear stimulus. The probability of avoidance behavior, defined as stopping the approach of
Harry Udin, Gary Olswanger, Roger E. Vogler   +2 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Automatic collision avoidance: towards the 21st century

, 1995
The importance of collision avoidance at sea is emphasised to cover four main aspects. A brief review of the research that has been carried out on automatic collision avoidance systems follows.
Wilson, P.A., Zhao, J., Price, W.G.
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Why do teachers procrastinate? The role of fear of negative evaluation and intolerance of uncertainty

Frontiers in Psychology
Academic procrastination has increasingly been recognized as a significant source of stress and professional dysfunction among teachers. However, the psychological mechanisms underlying this behavior are not yet fully understood.
Ema Di Petrillo, Ema Di Petrillo, Jerónimo Javier Gonález-Bernal, Matteo Villanova, Valeria Caggiano, Juana María Gutiérrez-Caballero, Luna Blázquez-Gutiérrez, Alberto Blázquez-Manzano, Paula Rodríguez-Fernández   +8 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source