Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Mechanisms of Motivation in Avoidance Behavior
, 1980 The mechanisms involved in avoidance behavior are discussed. It is assumed that the conditioned stimulus (CS) activates the memory pattern of associations related to the former applications of the unconditioned stimulus (US) and, as a result, produces an undesirable sensory state.
openaire +2 more sources
The Ontogeny of the generalisation of avoidance behaviour
Developmental PsychobiologyThe developmental trajectory of the generalisation of avoidance has received limited research attention, despite generalisation and avoidance being key features of anxiety disorders. This study used a gamified avoidance task to investigate generalisation in 96 children aged 5–11 years old.
Courteney Tiegan Louise Fisher +2 more
openaire +2 more sources
Water Quality Violations and Avoidance Behavior: Evidence from Bottled Water Consumption [PDF]
In this paper, we examine the impact of poor water quality on avoidance behavior by estimating the change in bottled water purchases in response to drinking water violations. Using data from a national grocery chain matched with water quality violations,
Joshua Graff Zivin +2 more
core
Color in context: psychological context moderates the influence of red on approach- and avoidance-motivated behavior. [PDF]
, 2012 A basic premise of the recently proffered color-in-context model is that the influence of color on psychological functioning varies as a function of the psychological context in which color is perceived.
Benjamin M. Wilkowski +22 more
core +2 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
LOCUS COERULEUS NOREPINEPHRINE IN ACTIVE AVOIDANCE AND REWARD SEEKING BEHAVIOR
Cue driven behavior relies on the ability to appropriately respond to stimuli in the environment to obtain resources (food, water, etc.) or avoid threats/danger.
Rodberg, Ellen
core +1 more source
‘Avoidance Preening’, Displacement Behavior and Co-Dependency in Professional Team Sport: When Wants Become More Important Than Needs [PDF]
, 2022 An athlete’s body plays an important role in their performance and well-being. However, game-relevant skills are better determinants of success, compared with physical fitness, in technically-driven team sports.
Blake D. McLean +2 more
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Analysis of the grounding avoidance behavior of a ro-pax ship in the gulf of finland using big data
, 2020 Waterway traffic complexity is one of the main reasons behind grounding accidents. It can be estimated qualitatively through expert judgment or quantitatively through the analysis of traffic data.
Montewka, Jakub +4 more
core +1 more source