Results 61 to 70 of about 2,663,717 (282)

Enhancing antibiotic stewardship: Physicians’ acceptance of AWaRe (Access, Watch, Reserve)-based microbiology reporting and its impact on judicious antibiotic selection – a cross-sectional study

GMS Hygiene and Infection Control
Background: Inappropriate and excessive use of antimicrobials contributes to the rise of antimicrobial resistance (AMR). To address this, better tools are needed to improve antibiotic prescribing globally.
Hassan, Heera, Reghukumar, Aravind, Rajahamsan, Jyothi, Harikumar, Sreenadh, Shanmugham, Manjusree   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A Noise-Aware Coding Scheme for Texture Classification [PDF]

Sensors, 2011
Texture-based analysis of images is a very common and much discussed issue in the fields of computer vision and image processing. Several methods have already been proposed to codify texture micro-patterns (texlets) in images. Most of these methods perform well when a given image is noise-free, but real world images contain different types of signal ...
Mohammad Shoyaib, Mohammad Abdullah-Al-Wadud, Oksam Chae   +2 more
openaire   +4 more sources

Potential strategies to limit inappropriate purchasing of antibiotics without a prescription in a rural province in South Africa: Pilot study and the implications

Advances in Human Biology
Introduction: There is considerable concern with rising rates of antimicrobial resistance (AMR) with its subsequent impact on morbidity, mortality and costs.
Tiyani Milta Sono, Morgan Tiyiselani Maluleke, Ana Golić Jelić, Stephen Campbell, Vanda Marković-Peković, Natalie Schellack, Santosh Kumar, Brian Godman, Johanna Catharina Meyer   +8 more
doaj   +1 more source

Lightweight Histological Tumor Classification Using a Joint Sparsity-Quantization Aware Training Framework

IEEE Access, 2023
Cancer decision-making is a complex process that can be exacerbated by the limited availability of oncological expertise. This is particularly true in rural areas and settings with fewer resources. Recently, there has been an interest in the potential of
Dina Aboutahoun, Rami Zewail, Keiji Kimura, Mostafa I. Soliman   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Utilisation of antibiotics in a community pharmacy: A case from north-west, South Africa

African Journal of Primary Health Care & Family Medicine
Background: Antibiotic utilisation is a growing public health issue due to antimicrobial resistance. Community pharmacies are a key access point for antibiotics; thus, an evaluation of dispensing records will provide insights into their use.
Zanele Nsingo, Varsha Bangalee, Deanne Johnston   +2 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source