Results 61 to 70 of about 47,738 (213)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Structural Performance of Columns with Glass Fiber-Reinforced Polymer Bars Under Axial Compression

Fibers
Corrosion continues to be a major challenge affecting the service life, safety and durability of steel-reinforced concrete (RC) structures. The deterioration of steel not only reduces structural capacity but also increases long-term maintenance costs. To
Trupti Amit Kinjawadekar, Shantharam Patil, Gopinatha Nayak   +2 more
doaj   +1 more source

Development of Axial Encoder to Measure Spindle Axial Motion

International Journal of Automation Technology, 2009
This paper deals with a newly developed axial encoder to measure spindle axial motion. The axial encoder was composed of a cylindrical rod with circular gratings and an optical encoder head. They were respectively mounted on the spindle nose and the worktable of a vertical milling machine.
Mitsuyoshi Nomura, Takahiro Kawashima, Takayuki Shibata, Yoshihiko Murakami, Masami Masuda, Osamu Horiuchi   +5 more
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Guías argentinas de práctica clínica, diagnóstico, evaluación y tratamiento en pacientes adultos con espondiloartritis axial

Revista Argentina de Reumatología
La espondiloartritis axial (EspAax) es una enfermedad crónica inflamatoria que incluye a la espondiloartritis radiográfica (EspAax-r) (anteriormente conocida como espondilitis anquilosante [EA]) y a la espondiloartritis axial no radiográfica (EspAax-nr)
María Victoria Martire, Mariana Benegas, Carla Airoldi, Natalia Zamora, Gustavo Citera, Enrique Soriano, Emilio Buschiazzo, Dafne Capelusnik, Tomás Cazenave, Vanesa Cosentino, Leandro Ferreyra Garrot, Rodrigo García Salinas, Carolina Isnardi, Maximiliano Machado Escobar, José Maldonado Cocco, Hernán Maldonado Fico, Josefina Marin, Romina Nieto, Rodolfo Pérez Alamino, Javier Eduardo Rosa, Fernando Sommerfleck, Diego Vila, Diana Fernández, Emilce E. Schneeberger   +23 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The computation of axial charge with axial divergence

Nuclear Physics B, 1967
Abstract The consequences of a certain commutator between the axial charge and the axial divergence constructed from the strangeness-changing weak axial-vector current are investigated. A value for the F / D ratio in good agreement with the experiment is obtained. Finally a discussion of compatibility with the quark model is given.
openaire   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source