Results 81 to 90 of about 5,747,014 (299)

Axial Spondyloarthritis

, 2016
Axial spondyloarthritis is the commonest inflammatory arthritis affecting the spine. Typically first presenting to a variety of primary and secondary care professionals, the high global disease burden of this condition has created a need for increased ...

core  

Rotor integrity design for a high-speed modular air-cored axial-flux permanent-magnet generator [PDF]

, 2011
The rotor integrity design for a high-speed modular air-cored axial-flux permanent-magnet (AFPM) generator is presented. The main focus is on the mechanical parametric optimization of the rotor, which becomes a more dominating design issue over ...
Luk, Patrick Chi-Kwong, El-Hasan, T. S., P. C. K. Luk, Fei, Wei-Zhong, W. Fei, T. S. El-Hasan   +5 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Age and initial spherical equivalent influence the axial length elongation in children aged 9–17 years undergoing orthokeratology therapy

BMC Ophthalmology
Background Orthokeratology (Ortho-K) lenses are increasingly used in children to manage myopia by reshaping the cornea and potentially influencing axial length changes.
Guangbin Zhong, Ruinian Zheng, Linyi Luo
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Kilkenny: age friendly county strategy [PDF]

, 2010
This document outlines a new and ambitious plan to improve the lives and well being of all older adults in Kilkenny. The strategy has been developed as a result of detailed consultation with the older people of Kilkenny, the agencies and service ...
Kilkenny Age Friendly County Alliance
core  

Age- and Myopia-Related 3-Dimensional Remodeling of Choroidal Thickness in Children

Ophthalmology Science
Purpose: To investigate the 3-dimensional (3D) topographic remodeling patterns of choroidal thickness (ChT) in the macular region in children, and their associations with age and myopia related ocular growth.
Luxiao Chen, MBBS, Jixuan Yuan, PhD, Ziyao Wang, MD, Zhe Pan, MD, Dan Zhu, MD, Zeyue Fan, MD, Di Zhang, MD, Ziyao Xia, MD, Jost B. Jonas, MD, PhD, Chong Li, PhD, Tien Yin Wong, MD, PhD, Ya Xing Wang, MD, PhD   +11 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Stochastic axial compressor variable geometry schedule optimisation [PDF]

, 2011
The design of axial compressors is dictated by the maximisation of flow efficiency at on design conditions whereas at part speed the requirement for operation stability prevails.
Singh, R., Pachidis, Vassilios, Vassilios Pachidis, Riti Singh, Manuel Arias, Gallar, L., Arias, M., Luis Gallar   +7 more
core   +1 more source