Results 61 to 70 of about 3,329,474 (283)
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Assessment of bearing capacity of axially loaded monopiles based on centrifuge tests
Ocean Engineering, 2018 Abstract The monopile has been widely used to support offshore and coastal structures. A series of centrifuge tests has been performed to investigate the bearing capacity of large diameter monopiles in sandy soil. Both static tests and cyclic tests have been conducted for open-ended and close-ended model piles, and the effects of influence factors ...
Xuefei Wang, Xiangwu Zeng, Jiale Li
openaire +2 more sources
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
BuildingsIn this study, three prefabricated integral shear wall specimens with strength differences were constructed based on a real engineering project to investigate the impact of these strength disparities on the structural performance of shear walls.
Jinghan Wang, Zhiyang Wei, Zhaohua Du
doaj +1 more source
Determination of axial bearing capacity of MEGA piles according to eurocode 7
, 2021 Short review of provisions of Eurocode 7 for determination of pile axial bearing capacity is given in this paper. Design guidelines and recommendations for determination of bearing capacity of jacked-in MEGA piles, according to pile installation technology and chosen design approach in National Annex for Eurocode 7 (Part 1) in Serbia are presented.
Obradović, Nikola +3 more
openaire +2 more sources
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Comparative study on prediction of axial bearing capacity of driven piles in granular materials [PDF]
, 2013 Estimation of axial bearing capacity plays an essential role in pile design. A part from semi-empirical and numerical methods, axial bearing capacity of piles can be either predicted by means of a maintain load test or dynamic load test.
Gofar, Nurly +3 more
core +2 more sources
Postfire reliability analysis of axial load bearing capacity of CFRP retrofitted concrete columns [PDF]
, 2020 A reliability analysis of the axial compressive load bearing capacity of postfire reinforced concrete (RC) columns strengthened with carbon fiber reinforced polymer (CFRP) sheets was presented.
Fu, F., Cai, B., Hao, L.
core +1 more source
Analytical model regarding compression-bending capacity of segmental joint reinforced by steel plate
Underground SpaceThe mechanical properties of the steel-plate-reinforced segmental lining are generally determined by the load-bearing capacity of reinforced joints.
Zhen Li, Xuezeng Liu
doaj +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source