Results 71 to 80 of about 2,898,126 (296)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Japan Architectural Review, 2019 During earthquakes, I‐shaped beams installed in a braced structure are subjected to a bending moment and compressive and tensile axial forces transmitted from the braces.
Yoshihiro Kimura +2 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Prediction of axial load capacity of concrete walls with openings restrained on three sides
, 2020 Currently, the empirical wall design equations given in major codes of practices either offer no guidelines or provide overly conservative predictions of the ultimate axial strength of concrete walls with openings restrained on three sides (TW3S walls ...
Guerrieri, Maurice +6 more
core +1 more source
The Axial Uplift Capacity of Screw Piles: A Review
Journal of EngineeringThere is a continuous demand in geotechnical engineering to find more economical footing. Screw piles provide acceptable or even much more bearing against tensile, compression, lateral, and overturning moment loads with less impact on the environment and surrounding buildings.
Ibrahim W. Ibrahim, Mahdi Karkush
openaire +2 more sources
Prediction of Axial Capacity of Concrete Filled Steel Tubes Using Gene Expression Programming. [PDF]
Materials (Basel), 2022 Khan K +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
BuildingsThis study aims to examine the effects of local corrosion on the axial compression performance of concrete-filled steel tubular (CFST) members. Nineteen CFST short columns with local corrosion were designed and fabricated to undergo axial compression ...
Wei Fang +5 more
doaj +1 more source