Results 51 to 60 of about 280,407 (351)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Experimental and Numerical Investigation of Characteristics of Highly Heterogeneous Rock Mechanical Responses in Tight Sandy Conglomerate Reservoir Rock Under Tri-axial Compression

Frontiers in Earth Science, 2021
Due to the use of horizontal wells and hydraulic fracturing, commercial tight oil production from some tight sandy conglomerate reservoirs has been achieved.
Bin Chen, Jiaqi Ji, Jingqi Lin, Huayong Chen, Xueliang Wang, Xuyang Guo, Xuyang Guo, Wentao Yang, Jiaying Lin, Jiaying Lin   +9 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Buckling strength of filament-wound cylinders under axial compression is investigated [PDF]

, 1967
Analytical study was made of the effects of axial compression on buckling strength of filament-wound cylinders having diameter-to-wall thickness ratios of 167 to 643.

core   +1 more source

Study on Creep Compression Characteristics of Pressure-Bearing Graded Crushed Rock

Buildings
To study the creep compression characteristics and evolution mechanism of pressure-bearing graded crushed rock under constant load. Creep compression tests of crushed rock were conducted using the self-developed confined compression test system under ...
Yu Tian, Mei Zhi, Jie Zhou, Pengfei Ji, Shitong Peng   +4 more
doaj   +1 more source

A yield curvature model considering axial compression ratio

Advances in Bridge Engineering, 2023
This study proposed a yield curvature prediction model considering axial compression ratio with exponential function which is improved on the basis of the specification effective yield curvature prediction model.
Yanyan Zhu, Jian Zhong
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Effect of Axial Compression Ratio on Seismic and Self-Centering Performance of Unbonded Prestressed Concrete Columns

Advances in Civil Engineering, 2022
To explore the influence of the applied axial compression ratio and preloaded axial compression ratio on the seismic performance of unbonded prestressed concrete columns, pseudo-static tests were carried out on four prestressed columns and one ordinary ...
Yun Shi, Guanglin Yuan, Hao Zhu
doaj   +1 more source

Off-axial Compressive Properties of 3-axially Reinforced 3D Composites.

Journal of the Japan Society for Composite Materials, 1996
Mechanical properties of multi-axis three-dimensional fabric composite materials are considered to be influenced by molding condition and molding defects. Off-axial compressive properties, which are sensitive to defects, have been studied for rod piercing type threeaxially reinforced threedimensional (3D3A) composites.
Masatoshi FURUYAMA, Kazutami MITANI, Kenji FUKUTA, Mitsuaki MATSUMOTO   +3 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source