Results 31 to 40 of about 29,718 (177)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Advances in Civil Engineering, 2020 This study evaluates the seismic behavior of reinforced concrete (RC) short columns with a high axial compression ratio under oblique earthquake conditions.
Chunyang Liu +4 more
doaj +1 more source
Frontiers in Built Environment, 2022 Concrete-filled steel tubular (CFST) structures using high-strength materials have been increasingly used in civil engineering due to their exceptional mechanical performance. A comprehensive numerical analysis was performed in this study, where a finite
Jie Hu, Wei Li
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Journal of Infrastructure Preservation and Resilience, 2021 Axial compression performance of concrete columns reinforced with 2304 solid stainless bars and spirals, carbon steel bars and spirals, and 316 L stainless steel clad bars is examined after the columns are exposed to severe corrosion.
John W. Wright, Chris P. Pantelides
doaj +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Buildings, 2023 To improve the shear performance and construction efficiency of horizontal joints in prefabricated concrete wall panel structures, an innovative keyway joint for prefabricated concrete wall panels is presented to maximize the contact area and joint ...
Laixiu Cheng +3 more
doaj +1 more source