Results 31 to 40 of about 27,854 (263)

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier   +11 more
wiley   +1 more source

Seismic Behavior and Finite Element Analysis of Reinforced Concrete Short Columns Impacted by Oblique Earthquakes

open access: yesAdvances in Civil Engineering, 2020
This study evaluates the seismic behavior of reinforced concrete (RC) short columns with a high axial compression ratio under oblique earthquake conditions.
Chunyang Liu   +4 more
doaj   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho   +7 more
wiley   +1 more source

Numerical Analysis on Post-Fire Resistance of High-Strength Circular CFST Stub Column in Axial Compression

open access: yesFrontiers in Built Environment, 2022
Concrete-filled steel tubular (CFST) structures using high-strength materials have been increasingly used in civil engineering due to their exceptional mechanical performance. A comprehensive numerical analysis was performed in this study, where a finite
Jie Hu, Wei Li
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Axial compression capacity of concrete columns reinforced with corrosion-resistant metallic reinforcement

open access: yesJournal of Infrastructure Preservation and Resilience, 2021
Axial compression performance of concrete columns reinforced with 2304 solid stainless bars and spirals, carbon steel bars and spirals, and 316 L stainless steel clad bars is examined after the columns are exposed to severe corrosion.
John W. Wright, Chris P. Pantelides
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Experimental and Numerical Investigation of the Shear Performance of an Innovative Keyway Joint for Prefabricated Concrete Wall Panels

open access: yesBuildings, 2023
To improve the shear performance and construction efficiency of horizontal joints in prefabricated concrete wall panel structures, an innovative keyway joint for prefabricated concrete wall panels is presented to maximize the contact area and joint ...
Laixiu Cheng   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

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