Results 41 to 50 of about 29,718 (177)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Experimental Performance Study on Axial Compressive Load-Bearing Capacity of Steel Slag Micropowder Ecotype UHPC of Short Columns Steel Pipe

Applied Sciences
In order to study the axial compression performance of steel pipe concrete short columns filled with steel slag micronized ultra-high-performance concrete (UHPC), this paper designs 27 steel pipe UHPC short columns for axial compression test and compares
Shangqi Guo, Xianyuan Tang, Chenzhuo Feng, Binbing He, Bai Yang   +4 more
doaj   +1 more source

Axial Compressive Performance of Steel-Reinforced Concrete Columns with Monosymmetric Cross-Shaped Steel

Advances in Civil Engineering, 2021
The axial compressive performance of steel-reinforced concrete columns with monosymmetric cross-shaped steel (SRCC-MCS) was investigated in this study.
Jipeng Yu, Tianhua Zhou, Yu Zhang, Yapeng Li   +3 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Research on axial compression performance test and bearing capacity calculation method of newly assembled hollow lattice wallboard

Frontiers in Materials
With the great development of the construction industry, prefabricated building components have been greatly developed. To study the compressive performance of the new wallboard, the axial compression performance test of six full-scale new lattice ...
Yunlin Liu, Yunlin Liu, Shangwei Huo, Zhixin Wu, Dingguo Yang, Ke Ren, Jianhua Liu, Riguang Wang   +7 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Bearing capacity of UHPC-filled circular steel tube short column under axial compression

Građevinar
This study establishes a predictive formula for the axial compression bearing capacity of Ultra High Performance Concrete (UHPC) filled circular steel tube (circular UHPCFST) short columns. The basis for establishing this formula is the derivation method
Shengbing Fang
doaj   +1 more source

Study on the Axial Compression Performance of UHPC-SRC Short Columns

Buildings
This study proposes a novel UHPC-SRC short column structure that adopts ultra-high performance concrete (UHPC) as a permanent formwork, combined with longitudinal reinforcement, stirrups, and H-shaped steel. The design aims to enhance construction efficiency and sustainability while maintaining excellent mechanical performance.
Ruochen Wang, Kun Wang, Xiaobin Wei
openaire   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source