Results 51 to 60 of about 7,231,162 (253)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
南方能源建设, 2023 [Introduction] The existing angle steel transmission tower has been running for many years, and the structural damage leads to the reduction of service performance.
Jinghui LI +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Plastic buckling of initially imperfect stiffened cylinders in axial compression [PDF]
, 1981 Bibliography: leaves 117-118.Bifurcation in the plastic range of axially compressed stringer-stiffened cylinders is investigated. The shell under consideration is assumed to have an initial imperfection in the form of a sinusoidal deviation both axially ...
Duffett, Gino Alan
core +1 more source
Bearing capacity of UHPC-filled circular steel tube short column under axial compression
GrađevinarThis study establishes a predictive formula for the axial compression bearing capacity of Ultra High Performance Concrete (UHPC) filled circular steel tube (circular UHPCFST) short columns. The basis for establishing this formula is the derivation method
Shengbing Fang
doaj +1 more source
上海师范大学学报. 自然科学版High strength steel welded box-shaped axial compression members have been widely used in steel structure engineering. In this paper, ANSYS analysis software was adopted to establish a finite element model considering the local geometrical initial defect ...
ZHAO Chuandou, YANG Yonghua
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Synchronization Overhead in SOC Compressed Test
, 2005 Test data compression is an enabling technology for low-cost test. Compression schemes however, require communication between the system under test and the automated test equipment.
Gonciari, Paul Theo +2 more
core +1 more source